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    Dh44-R1 Diuretic hormone 44 receptor 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36601, updated on 17-Dec-2024

    Summary

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    Official Symbol
    Dh44-R1provided by FlyBase
    Official Full Name
    Diuretic hormone 44 receptor 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0033932
    Locus tag
    Dmel_CG8422
    See related
    AllianceGenome:FB:FBgn0033932
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0170980.100; anon-WO0170980.101; CG8422; DH-R; DH44-R1; Dh44R1; DH44R1; DH[[44]]-R1; DmeCG8422; Dmel\CG8422
    Summary
    Enables diuretic hormone receptor activity. Involved in G protein-coupled receptor signaling pathway and hormone-mediated signaling pathway. Located in plasma membrane. Is expressed in several structures, including adult abdominal neuromere; adult brain; central nervous system; larval MP3 neuron; and synaptic neuropil domain. Human ortholog(s) of this gene implicated in asthma; chronic obstructive pulmonary disease; and obesity. Orthologous to several human genes including LINC02210-CRHR1 (LINC02210-CRHR1 readthrough) and CRHR1 (corticotropin releasing hormone receptor 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Dh44-R1 in Genome Data Viewer
    Location:
    50F8-50F9; 2-70 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (14378097..14385359)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (10265602..10272864)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Odorant-binding protein 50e Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44369

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. New insights into the evolution of vertebrate CRH (corticotropin-releasing hormone) and invertebrate DH44 (diuretic hormone 44) receptors in metazoans. Cardoso JC, et al. Gen Comp Endocrinol, 2014 Dec 1. PMID 25230393
    2. Repetitive aggressive encounters generate a long-lasting internal state in Drosophila melanogaster males. Kim YK, et al. Proc Natl Acad Sci U S A, 2018 Jan 30. PMID 29339481, Free PMC Article
    3. Drosophila GPCR Han is a receptor for the circadian clock neuropeptide PDF. Hyun S, et al. Neuron, 2005 Oct 20. PMID 16242407
    4. Nematode and arthropod genomes provide new insights into the evolution of class 2 B1 GPCRs. Cardoso JC, et al. PLoS One, 2014. PMID 24651821, Free PMC Article
    5. Cellular dissection of circadian peptide signals with genetically encoded membrane-tethered ligands. Choi C, et al. Curr Biol, 2009 Jul 28. PMID 19592252, Free PMC Article

    See all (84) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A population of neurons that produce hugin and express the diuretic hormone 44 receptor gene projects to the corpora allata in Drosophila melanogaster.
      Title: A population of neurons that produce hugin and express the diuretic hormone 44 receptor gene projects to the corpora allata in Drosophila melanogaster.
    2. The DH44 PI-Hugin SEZ circuit controls circadian locomotor activity in a daily cycle but has minimal effect on feeding rhythms, suggesting that the circadian drive to feed can be separated from circadian locomotion.
      Title: A Peptidergic Circuit Links the Circadian Clock to Locomotor Activity.
    3. The Dh44/DH44 receptor system directs the detection and consumption of nutritive sugars through a positive feedback loop.
      Title: Nutrient Sensor in the Brain Directs the Action of the Brain-Gut Axis in Drosophila.
    4. Fundamental differences in signaling, association with the arrestins, and peptide sensitivity between CG8422 and CG12370 are discussed.
      Title: Functional differences between two CRF-related diuretic hormone receptors in Drosophila.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables G protein-coupled peptide receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcitonin receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables diuretic hormone receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables diuretic hormone receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables diuretic hormone receptor activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables diuretic hormone receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables neuropeptide receptor activity ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    enables peptide hormone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    involved_in G protein-coupled receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell surface receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in hormone-mediated signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    diuretic hormone 44 receptor 1
    Names
    CG8422-PA
    CRF-like diuretic hormone receptor 1
    DH44 receptor
    DH44-receptor
    DH[[44]] receptor
    Dh44 receptor 1
    Dh44-R1-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      14378097..14385359
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_137116.3 → NP_610960.1  diuretic hormone 44 receptor 1 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610960.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z9Q8
      Related
      FBpp0086614
      Conserved Domains (2) summary
      cd15263
      Location:126 → 394
      7tmB1_DH_R; insect diuretic hormone receptors, member of the class B family of seven-transmembrane G protein-coupled receptors
      pfam02793
      Location:52 → 112
      HRM; Hormone receptor domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1Z9Q8 A1Z9Q8
    Q8SWX5 Q8SWX5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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