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    CG7379 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42140, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG7379provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0038546
    Locus tag
    Dmel_CG7379
    See related
    AllianceGenome:FB:FBgn0038546
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG7339; Dmel\CG7379; Ing1; ING1
    Summary
    Predicted to enable methylated histone binding activity. Predicted to be involved in positive regulation of DNA-templated transcription. Part of Sin3-type complex. Is expressed in several structures, including CNS glial cell; anterior endoderm; embryonic/larval midgut primordium; ganglia; and neuroblasts. Used to study carcinoma. Human ortholog(s) of this gene implicated in head and neck squamous cell carcinoma and squamous cell carcinoma. Orthologous to several human genes including ING2 (inhibitor of growth family member 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG7379 in Genome Data Viewer
    Location:
    90C5-90C5; 3-61 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (17796376..17798304, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (13622098..13624026, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene pasiflora 1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Nicknack

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. CG7379 and ING1 suppress cancer cell invasion by maintaining cell-cell junction integrity. Rusu AD, et al. Open Biol, 2021 Sep. PMID 34493070, Free PMC Article
    2. Systematic Analysis of SIN3 Histone Modifying Complex Components During Development. Barnes VL, et al. Sci Rep, 2018 Nov 19. PMID 30451916, Free PMC Article
    3. Drosophila SIN3 isoforms interact with distinct proteins and have unique biological functions. Spain MM, et al. J Biol Chem, 2010 Aug 27. PMID 20566628, Free PMC Article
    4. Pasiflora proteins are novel core components of the septate junction. Deligiannaki M, et al. Development, 2015 Sep 1. PMID 26329602, Free PMC Article
    5. The Nucleosome Remodeling and Deacetylase Complex NuRD Is Built from Preformed Catalytically Active Sub-modules. Zhang W, et al. J Mol Biol, 2016 Jul 17. PMID 27117189, Free PMC Article

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables methylated histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of Sin3-type complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG7379-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      17796376..17798304 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_142399.3 → NP_650656.1  uncharacterized protein Dmel_CG7379 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650656.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VEF5
      Related
      FBpp0082953
      Conserved Domains (2) summary
      cd15584
      Location:360 → 404
      PHD_ING1_2; PHD finger found in inhibitor of growth protein 1 (ING1) and 2 (ING2)
      pfam12998
      Location:17 → 116
      ING; Inhibitor of growth proteins N-terminal histone-binding
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VEF5 Q9VEF5

    Gene LinkOut

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