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    pont pontin [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 53439, updated on 9-Dec-2024

    Summary

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    Official Symbol
    pontprovided by FlyBase
    Official Full Name
    pontinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0040078
    Locus tag
    Dmel_CG4003
    See related
    AllianceGenome:FB:FBgn0040078
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    0229/05; anon-WO0118547.698; CG4003; Dmel\CG4003; dpon; dPon; dPontin; dRUVBL1; l(3)S022905; pon; PON; Pont; PONT; Pontin; RUVBL1; Tip49; Tip49/Pontin
    Summary
    Enables transcription coactivator activity. Involved in several processes, including DNA repair-dependent chromatin remodeling; mitotic spindle assembly; and regulation of signal transduction. Located in nucleus. Part of R2TP complex and chromatin. Is expressed in several structures, including embryonic/larval midgut primordium; endoderm anlage; mesoderm; sensory nervous system primordium; and visceral mesoderm derivative. Orthologous to human RUVBL1 (RuvB like AAA ATPase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See pont in Genome Data Viewer
    Location:
    86A3-86A3; 3-49 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (10262123..10263899)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (6087845..6089621)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Sirtuin 6 Neighboring gene Nuak family kinase Neighboring gene transfer RNA:Serine-GCT 2-1 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A Critical Review of Animal Models Used in Acute Myeloid Leukemia Pathophysiology. Skayneh H, et al. Genes (Basel), 2019 Aug 13. PMID 31412687, Free PMC Article
    2. Rvb1-Rvb2: essential ATP-dependent helicases for critical complexes. Huen J, et al. Biochem Cell Biol, 2010 Feb. PMID 20130677
    3. Pontin is a critical regulator for AML1-ETO-induced leukemia. Breig O, et al. Leukemia, 2014 Jun. PMID 24342949
    4. Myc interacts genetically with Tip48/Reptin and Tip49/Pontin to control growth and proliferation during Drosophila development. Bellosta P, et al. Proc Natl Acad Sci U S A, 2005 Aug 16. PMID 16087886, Free PMC Article
    5. Pontin/Tip49 negatively regulates JNK-mediated cell death in Drosophila. Wang X, et al. Cell Death Discov, 2018. PMID 30062057, Free PMC Article

    See all (97) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. WAC promotes the interaction between TTT and Pontin/Reptin in an energy-dependent manner, thereby promoting mTORC1 activity by facilitating mTORC1 dimerization and mTORC1-Rag interaction
      Title: WAC Regulates mTOR Activity by Acting as an Adaptor for the TTT and Pontin/Reptin Complexes.
    2. two newly identified factors that restrict diverse viruses, dXPO1 and dRUVBL1 contributed to antiviral defense at the organismal level in adult flies
      Title: Genome-wide RNAi screen identifies broadly-acting host factors that inhibit arbovirus infection.
    3. Pontin has a mitosis-specific function in regulating microtubule assembly
      Title: Regulation of microtubule assembly and organization in mitosis by the AAA+ ATPase Pontin.
    4. The enzymatic functions of Rept and Pont are indispensable for maintaining Hox gene expression states, highlighting the importance of these two antagonistic factors in transcriptional output.
      Title: Reptin and Pontin function antagonistically with PcG and TrxG complexes to mediate Hox gene control.
    5. reptin and pontin have conserved their ability to bind to Myc during evolution
      Title: Myc interacts genetically with Tip48/Reptin and Tip49/Pontin to control growth and proliferation during Drosophila development.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent activity, acting on DNA IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription coactivator activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA repair-dependent chromatin remodeling IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in box C/D snoRNP assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chromatin remodeling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chromatin remodeling IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in mitotic spindle assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of JNK cascade IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of negative regulation of programmed cell death IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of tumor necrosis factor-mediated signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of canonical Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of Ino80 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Ino80 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of NuA4 histone acetyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of NuA4 histone acetyltransferase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of R2TP complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of R2TP complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of Swr1 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of brahma complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    pontin
    Names
    CG4003-PA
    dpontin
    pont-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      10262123..10263899
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_144351.4 → NP_652608.1  pontin [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_652608.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9NH53, Q9VH06, Q9VH07
      Related
      FBpp0081704
      Conserved Domains (2) summary
      pfam06068
      Location:14 → 413
      TIP49; TIP49 C-terminus
      cl21455
      Location:66 → 110
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VH07.1 Q9VH07

    Gene LinkOut

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    Other Literature Sources
    Chemical Information
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