nAChRalpha4 nicotinic Acetylcholine Receptor alpha4 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: nAChRalpha4provided by FlyBase
Official Full Name: nicotinic Acetylcholine Receptor alpha4provided by FlyBase
Primary source: FLYBASE:FBgn0266347
Locus tag: Dmel_CG12414
See related: AllianceGenome:FB:FBgn0266347
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: alpha4; anon-WO0138359.1; CG12414; CG17552; Dalpha4; Dmel\CG12414; nAChR; nAChR-alpha80B; nAChRa4; nAcRalpha-4; nAcRalpha-80; nAcRalpha-80B; nAcRaplha-80B; redeye; rye
Summary: Contributes to acetylcholine receptor activity. Involved in sleep. Part of acetylcholine-gated channel complex. Is expressed in adult head; lamina monopolar neuron L4; and organism. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; autosomal dominant nocturnal frontal lobe epilepsy (multiple); congenital myasthenic syndrome (multiple); gastrointestinal system cancer (multiple); and respiratory system cancer (multiple). Orthologous to several human genes including CHRNA6 (cholinergic receptor nicotinic alpha 6 subunit). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 80D5-80E3; 3-47 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (23206669..23287448)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (23199769..23280548)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Propose that the homeostatic drive to sleep increases levels of RYE, which responds to this drive by promoting sleep.
Title: Identification of Redeye, a new sleep-regulating protein whose expression is modulated by sleep amount.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

mobile_element

Loc: 23214034-23214082 mobile_element_type = transposon:INE-1{}3754
Loc: 23218788-23219072 mobile_element_type = transposon:INE-1{}3758
Loc: 23219681-23219797 mobile_element_type = transposon:297{}3807
Loc: 23219852-23224264 mobile_element_type = transposon:X{}1606
Loc: 23228423-23228527 mobile_element_type = transposon:INE-1{}3769
Loc: 23241916-23243038 mobile_element_type = transposon:1360{}1171
Loc: 23248105-23248334 mobile_element_type = transposon:INE-1{}4510
Loc: 23252656-23252973 mobile_element_type = transposon:INE-1{}4512
Loc: 23256350-23256483 mobile_element_type = transposon:G5{}5176
Loc: 23267007-23267531 mobile_element_type = transposon:Cr1a{}1170
Loc: 23271761-23276816 mobile_element_type = transposon:invader2{}1169
Loc: 23277858-23277953 mobile_element_type = transposon:INE-1{}4524
Loc: 23279422-23279467 mobile_element_type = transposon:Cr1a{}5145
Loc: 23279468-23283577 mobile_element_type = transposon:Cr1a{}1607
Loc: 23279613-23279961 mobile_element_type = transposon:gypsy8{}5279
Loc: 23282059-23283258 mobile_element_type = transposon:looper1{}5747
Loc: 23286500-23286608 mobile_element_type = transposon:INE-1{}4535

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
contributes_to acetylcholine receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables acetylcholine-gated monoatomic cation-selective channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables acetylcholine-gated monoatomic cation-selective channel activity	IEA Inferred from Electronic Annotation more info
enables extracellular ligand-gated monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info
enables transmembrane signaling receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
involved_in monoatomic ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of membrane potential	IBA Inferred from Biological aspect of Ancestor more info
involved_in sleep	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of acetylcholine-gated channel complex	IBA Inferred from Biological aspect of Ancestor more info
part_of acetylcholine-gated channel complex	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in postsynaptic membrane	IEA Inferred from Electronic Annotation more info
is_active_in synapse	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: nicotinic acetylcholine receptor alpha4

Names: CG12414-PC; CG12414-PD; CG12414-PE; CG12414-PF; CG12414-PG; CG12414-PH; Dalpha4; nAChRalpha4-PC; nAChRalpha4-PD; nAChRalpha4-PE; nAChRalpha4-PF; nAChRalpha4-PG; nAChRalpha4-PH; nicotinic acetylcholine receptor alpha 4; nicotinic acetylcholine receptor alpha 80B; red-eye; redeye

NP_001097669.2

unusual splice

NP_001246895.1

unusual splice

NP_001246896.1

unusual splice

NP_001303394.1

unusual splice

NP_536742.3

unusual splice

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

23206669..23287448

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001104199.5 → NP_001097669.2 nicotinic acetylcholine receptor alpha4, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001097669.2

Status: REVIEWED

UniProtKB/TrEMBL

A8JNX5, Q9NFR5

Conserved Domains (3) summary

TIGR00860
Location:1 → 505

LIC; Cation transporter family protein

pfam02931
Location:12 → 227

Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain

pfam02932
Location:234 → 505

Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region
NM_001316465.1 → NP_001303394.1 nicotinic acetylcholine receptor alpha4, isoform H [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

A0A0S0WNY8, Q9NFR5

Conserved Domains (3) summary

TIGR00860
Location:1 → 505

LIC; Cation transporter family protein

pfam02931
Location:12 → 227

Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain

pfam02932
Location:234 → 505

Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region
NM_001259966.3 → NP_001246895.1 nicotinic acetylcholine receptor alpha4, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001246895.1

Status: REVIEWED

UniProtKB/TrEMBL

M9NE13, Q058T0

Conserved Domains (2) summary

pfam02931
Location:3 → 59

Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain

pfam02932
Location:66 → 337

Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region
NM_001259967.2 → NP_001246896.1 nicotinic acetylcholine receptor alpha4, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001246896.1

Status: REVIEWED

UniProtKB/TrEMBL

M9NE13, Q058T0

Conserved Domains (2) summary

pfam02931
Location:3 → 59

Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain

pfam02932
Location:66 → 337

Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region
NM_001275305.1 → NP_001262234.1 nicotinic acetylcholine receptor alpha4, isoform G [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001262234.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PDC9, Q9NFR5

Conserved Domains (3) summary

TIGR00860
Location:1 → 465

LIC; Cation transporter family protein

pfam02931
Location:12 → 227

Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain

pfam02932
Location:234 → 465

Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region
NM_080494.3 → NP_536742.3 nicotinic acetylcholine receptor alpha4, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_536742.3

Status: REVIEWED

UniProtKB/TrEMBL

Q058T0, Q95RL8

Conserved Domains (2) summary

pfam02931
Location:6 → 72

Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain

pfam02932
Location:79 → 350

Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region