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    Tbc1d22 TBC1 domain family member 22 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42498, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tbc1d22provided by FlyBase
    Official Full Name
    TBC1 domain family member 22provided by FlyBase
    Primary source
    FLYBASE:FBgn0038855
    Locus tag
    Dmel_CG5745
    See related
    AllianceGenome:FB:FBgn0038855
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG5745; Dmel\CG5745; dTBC1D22
    Summary
    Enables GTPase activator activity. Located in cytosol. Is expressed in organism. Orthologous to human TBC1D22A (TBC1 domain family member 22A) and TBC1D22B (TBC1 domain family member 22B). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Tbc1d22 in Genome Data Viewer
    Location:
    93B12-93B12; 3-70 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (21102199..21105113)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (16927921..16930835)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Rho GTPase activating protein at 93B Neighboring gene long non-coding RNA:CR44178 Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR46045 Neighboring gene Secretory 15 Neighboring gene tetracycline resistance Neighboring gene Rab11

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mutations in Drosophila sec15 reveal a function in neuronal targeting for a subset of exocyst components. Mehta SQ, et al. Neuron, 2005 Apr 21. PMID 15848801
    2. Regulation of lipid homeostasis by the TBC protein dTBC1D22 via modulation of the small GTPase Rab40 to facilitate lipophagy. Duan X, et al. Cell Rep, 2021 Aug 31. PMID 34469730
    3. Evolution of Tre-2/Bub2/Cdc16 (TBC) Rab GTPase-activating proteins. Gabernet-Castello C, et al. Mol Biol Cell, 2013 May. PMID 23485563, Free PMC Article
    4. Genetic modifiers of abnormal organelle biogenesis in a Drosophila model of BLOC-1 deficiency. Cheli VT, et al. Hum Mol Genet, 2010 Mar 1. PMID 20015953, Free PMC Article
    5. Evi5 promotes collective cell migration through its Rab-GAP activity. Laflamme C, et al. J Cell Biol, 2012 Jul 9. PMID 22778279, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Regulation of lipid homeostasis by the TBC protein dTBC1D22 via modulation of the small GTPase Rab40 to facilitate lipophagy.
      Title: Regulation of lipid homeostasis by the TBC protein dTBC1D22 via modulation of the small GTPase Rab40 to facilitate lipophagy.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GTPase activator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    TBC1 domain family member 22
    Names
    CG5745-PA
    Tbc1d22-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      21102199..21105113
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_142684.3 → NP_650941.3  TBC1 domain family member 22 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650941.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95RC5, Q9VDE7
      Related
      FBpp0083411
      Conserved Domains (1) summary
      smart00164
      Location:243 → 496
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q95RC5 Q95RC5

    Gene LinkOut

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