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    CG10353 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32148, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG10353provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0030349
    Locus tag
    Dmel_CG10353
    See related
    AllianceGenome:FB:FBgn0030349
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG10353
    Summary
    Predicted to enable intracellularly calcium-gated chloride channel activity. Predicted to be involved in chloride transmembrane transport. Predicted to be located in extracellular exosome. Predicted to be active in plasma membrane. Is expressed in adult head. Human ortholog(s) of this gene implicated in Moyamoya disease. Orthologous to human ANO1 (anoctamin 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG10353 in Genome Data Viewer
    Location:
    10F2-10F4; 1-37 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (11877737..11887162, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (11771770..11781195, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene BLOC-1 related complex subunit 5 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Selenoprotein G Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Phylogeny of the TMEM16 protein family: some members are overexpressed in cancer. Galindo BE, et al. Int J Mol Med, 2005 Nov. PMID 16211264
    2. Wispy, the Drosophila homolog of GLD-2, is required during oogenesis and egg activation. Cui J, et al. Genetics, 2008 Apr. PMID 18430932, Free PMC Article
    3. Isolation of gene sets affected specifically by polyglutamine expression: implication of the TOR signaling pathway in neurodegeneration. Nelson B, et al. Cell Death Differ, 2005 Aug. PMID 15861189
    4. Comparison of parallel high-throughput RNA sequencing between knockout of TDP-43 and its overexpression reveals primarily nonreciprocal and nonoverlapping gene expression changes in the central nervous system of Drosophila. Hazelett DJ, et al. G3 (Bethesda), 2012 Jul. PMID 22870402, Free PMC Article
    5. Genome-wide features of neuroendocrine regulation in Drosophila by the basic helix-loop-helix transcription factor DIMMED. Hadžić T, et al. Nucleic Acids Res, 2015 Feb 27. PMID 25634895, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables chloride channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables intracellularly calcium-gated chloride channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chloride transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chloride transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular exosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG10353-PC
    CG10353-PD
    CG10353-PE
    CG10353-PF
    CG10353-PI
    CG10353-PK
    CG10353-PL

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      11877737..11887162 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001272540.1 → NP_001259469.1  uncharacterized protein Dmel_CG10353, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259469.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D3PFF9, Q76NS2
      Conserved Domains (2) summary
      pfam04547
      Location:395 → 977
      Anoctamin; Calcium-activated chloride channel
      pfam16178
      Location:183 → 392
      Anoct_dimer; Dimerization domain of Ca+-activated chloride-channel, anoctamin

    2. NM_132534.4 → NP_572762.2  uncharacterized protein Dmel_CG10353, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572762.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MT62, Q9VYS8
      Conserved Domains (2) summary
      pfam04547
      Location:350 → 932
      Anoctamin; Calcium-activated chloride channel
      pfam16178
      Location:138 → 347
      Anoct_dimer; Dimerization domain of Ca+-activated chloride-channel, anoctamin

    3. NM_001272541.2 → NP_001259470.2  uncharacterized protein Dmel_CG10353, isoform L [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259470.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      D3PFF9, M9PGX9
      Conserved Domains (2) summary
      pfam04547
      Location:379 → 961
      Anoctamin; Calcium-activated chloride channel
      pfam16178
      Location:167 → 376
      Anoct_dimer; Dimerization domain of Ca+-activated chloride-channel, anoctamin

    4. NM_001272543.1 → NP_001259472.1  uncharacterized protein Dmel_CG10353, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259472.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MT62, Q9VYS8
      Conserved Domains (2) summary
      pfam04547
      Location:350 → 932
      Anoctamin; Calcium-activated chloride channel
      pfam16178
      Location:138 → 347
      Anoct_dimer; Dimerization domain of Ca+-activated chloride-channel, anoctamin

    5. NM_167312.4 → NP_727578.3  uncharacterized protein Dmel_CG10353, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_727578.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      D3PFF9, Q76NS2
      Conserved Domains (2) summary
      pfam04547
      Location:395 → 977
      Anoctamin; Calcium-activated chloride channel
      pfam16178
      Location:183 → 392
      Anoct_dimer; Dimerization domain of Ca+-activated chloride-channel, anoctamin

    6. NM_001272544.2 → NP_001259473.2  uncharacterized protein Dmel_CG10353, isoform K [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259473.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PJJ8, Q8MT62
      Conserved Domains (2) summary
      pfam04547
      Location:366 → 948
      Anoctamin; Calcium-activated chloride channel
      pfam16178
      Location:154 → 363
      Anoct_dimer; Dimerization domain of Ca+-activated chloride-channel, anoctamin

    7. NM_001258704.1 → NP_001245633.1  uncharacterized protein Dmel_CG10353, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245633.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D3PFF9, Q76NS2
      Conserved Domains (2) summary
      pfam04547
      Location:395 → 977
      Anoctamin; Calcium-activated chloride channel
      pfam16178
      Location:183 → 392
      Anoct_dimer; Dimerization domain of Ca+-activated chloride-channel, anoctamin
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PGX9 M9PGX9
    M9PJJ8 M9PJJ8
    Q76NS2 Q76NS2
    Q8MT62 Q8MT62
    Q9VYS8 Q9VYS8

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