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    Polr1A RNA polymerase I subunit A [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36617, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Polr1Aprovided by FlyBase
    Official Full Name
    RNA polymerase I subunit Aprovided by FlyBase
    Primary source
    FLYBASE:FBgn0019938
    Locus tag
    Dmel_CG10122
    See related
    AllianceGenome:FB:FBgn0019938
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    153129_at; CG10122; Dmel\CG10122; DmRPA1; RPA1; RPA190; RpI1; Rpl1
    Summary
    Predicted to enable DNA binding activity and DNA-directed 5'-3' RNA polymerase activity. Predicted to contribute to RNA polymerase I activity. Predicted to be involved in transcription by RNA polymerase I. Predicted to be part of RNA polymerase I complex. Is expressed in adult head. Human ortholog(s) of this gene implicated in acrofacial dysostosis Cincinnati type and hypomyelinating leukodystrophy. Orthologous to human POLR1A (RNA polymerase I subunit A). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Polr1A in Genome Data Viewer
    Location:
    51B4-51B6; 2-72 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (14595611..14601216, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (10483116..10488721, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene tout-velu Neighboring gene uncharacterized protein Neighboring gene Lamin C Neighboring gene uncharacterized protein Neighboring gene small Cajal body-specific RNA : PsiU5-44 Neighboring gene Biogenesis of lysosome-related organelles complex 1, subunit 1 Neighboring gene transformer 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of the gene coding for the largest subunit of RNA polymerase I (A) of Drosophila melanogaster. Knackmuss S, et al. Mol Gen Genet, 1997 Feb 20. PMID 9065685
    2. Molecular cloning and characterization of the cDNA encoding the largest subunit of mouse RNA polymerase I. Seither P, et al. Mol Gen Genet, 1997 Jun. PMID 9236775
    3. Partial Inhibition of RNA Polymerase I Promotes Animal Health and Longevity. Martínez Corrales G, et al. Cell Rep, 2020 Feb 11. PMID 32049000, Free PMC Article
    4. Heterochromatin protein 2 (HP2), a partner of HP1 in Drosophila heterochromatin. Shaffer CD, et al. Proc Natl Acad Sci U S A, 2002 Oct 29. PMID 12376620, Free PMC Article
    5. The steroid hormone ecdysone controls systemic growth by repressing dMyc function in Drosophila fat cells. Delanoue R, et al. Dev Cell, 2010 Jun 15. PMID 20627082

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-directed 5'-3' RNA polymerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to RNA polymerase I activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to RNA polymerase I activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transcription by RNA polymerase I ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of RNA polymerase I complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of RNA polymerase I complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    RNA polymerase I subunit A
    Names
    CG10122-PA
    Polr1A-PA
    RNA polymerase I
    RNA polymerase I subunit
    NP_523743.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      14595611..14601216 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079019.3 → NP_523743.1  RNA polymerase I subunit A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523743.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P91875, Q8MRE2, Q9V732
      Related
      FBpp0086640
      Conserved Domains (5) summary
      cd02735
      Location:1166 → 1638
      RNAP_I_Rpa1_C; Largest subunit (Rpa1) of Eukaryotic RNA polymerase I (RNAP I), C-terminal domain
      cd01435
      Location:18 → 982
      RNAP_I_RPA1_N; Largest subunit (RPA1) of eukaryotic RNA polymerase I (RNAP I), N-terminal domain
      TIGR02390
      Location:14 → 1009
      RNA_pol_rpoA1; DNA-directed RNA polymerase subunit A'
      pfam04998
      Location:936 → 1593
      RNA_pol_Rpb1_5; RNA polymerase Rpb1, domain 5
      cl00082
      Location:1057 → 1119
      HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P91875.2 P91875

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