svp seven up [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: svpprovided by FlyBase
Official Full Name: seven upprovided by FlyBase
Primary source: FLYBASE:FBgn0003651
Locus tag: Dmel_CG11502
See related: AllianceGenome:FB:FBgn0003651
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 0005/12; 0042/01; 0106/18; 0114/20; 0351/01; 0598/01; 0861/07; BcDNA:GH08189; CG11502; CG18158; ck16; Dmel\CG11502; don; l(3)07842; l(3)87Bd; l(3)ck16; l(3)j2E2; l(3)rA028; l(3)rL069; NR2F3; Seven-up; Svp; SVP; SVP-1; SVP1
Summary: Enables DNA-binding transcription repressor activity, RNA polymerase II-specific; protein heterodimerization activity; and protein homodimerization activity. Involved in several processes, including cardioblast cell fate determination; epithelial cell proliferation involved in Malpighian tubule morphogenesis; and neurogenesis. Located in cytoplasm. Is expressed in several structures, including apterous-expressing neuron of the lateral cluster of the thorax; dorsal vessel wall cell; glial cell; neuroblasts; and photoreceptor neurons. Used to study type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in 46,XX sex reversal 5 and Bosch-Boonstra-Schaaf optic atrophy syndrome. Orthologous to several human genes including NR2F2 (nuclear receptor subfamily 2 group F member 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 87B4-87B5; 3-52 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (12258737..12302785)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (8084459..8128507)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Authors propose that the Seven-up-initiated Imp/Syp gradients create coarse temporal windows within type II neuroblasts to pattern INPs, which subsequently undergo fine-tuned subtemporal patterning.
Title: Stem Cell-Intrinsic, Seven-up-Triggered Temporal Factor Gradients Diversify Intermediate Neural Progenitors.
A novel allele of svp was isolated. Expression analysis showed that svp is expressed in two distinct pulses in the embryonic NB5-6T lineage.
Title: Seven up acts as a temporal factor during two different stages of neuroblast 5-6 development.
Dan/Danr and Svp act in parallel pathways to limit Hb expression and allow neuroblasts to transition from making early-born neurons to late-born neurons at the proper time.
Title: The pipsqueak-domain proteins Distal antenna and Distal antenna-related restrict Hunchback neuroblast expression and early-born neuronal identity.
Normal patterning of alary muscles along the dorsal vessel was found to be a function of the Bithorax Complex genes abdominal-A (abd-A) and Ultrabithorax (Ubx) but not of the orphan nuclear receptor gene svp.
Title: Bithorax complex genes control alary muscle patterning along the cardiac tube of Drosophila.
Results suggest that svp is required for the differentiation of Eve-positive pericardial cells and DA1 muscle founders and may have a role in EPC cell growth
Title: Role of svp in Drosophila pericardial cell growth.
N represses Svp expression, thereby exposing an underlying stochastic choice between the R7 and R8 photoreceptor fates, and then tips this choice towards the R7 fate.
Title: Loss of seven-up from Drosophila R1/R6 photoreceptors reveals a stochastic fate choice that is normally biased by Notch.
Enhancer of svp is initially activated by the NK homeodomain factor Tinman (Tin) via two conserved Tin binding sites.
Title: The NK homeodomain transcription factor Tinman is a direct activator of seven-up in the Drosophila dorsal vessel.
Appropriate recruitment of the R3/R4 photoreceptor pair mediated by svp is a necessary prerequisite for the correct response of the ommatidial precluster to the Fz polarity signal.
Title: Linking cell-fate specification to planar polarity: determination of the R3/R4 photoreceptors is a prerequisite for the interpretation of the Frizzled mediated polarity signal.
svp modifies the self-renewal stem cell program to allow chronological change of cell fates, thereby generating neuronal diversity.
Title: seven-up Controls switching of transcription factors that specify temporal identities of Drosophila neuroblasts.
Results suggest that the differential regulation of Hunchback is achieved by a mechanism that integrates information created by the asymmetric distribution of Seven-up and Prospero.
Title: Timing of identity: spatiotemporal regulation of hunchback in neuroblast lineages of Drosophila by Seven-up and Prospero.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables nuclear receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables nuclear receptor activity	NAS Non-traceable Author Statement more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein heterodimerization activity	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in R1/R6 cell fate commitment	TAS Traceable Author Statement more info	PubMed
involved_in R3/R4 cell fate commitment	TAS Traceable Author Statement more info	PubMed
involved_in cardioblast cell fate determination	IEP Inferred from Expression Pattern more info	PubMed
involved_in cardioblast cell fate determination	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in epithelial cell proliferation involved in Malpighian tubule morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in fat body development	TAS Traceable Author Statement more info	PubMed
involved_in glial cell development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glucose homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heart development	TAS Traceable Author Statement more info	PubMed
involved_in lipid homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nervous system development	IBA Inferred from Biological aspect of Ancestor more info
involved_in neuroblast development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron-neuron synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in photoreceptor cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phototaxis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of lipid storage	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in ventral cord development	HMP more info	PubMed
involved_in ventral cord development	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: seven up

Names: CG11502-PA; CG11502-PB; CG11502-PC; CG11502-PE; CG11502-PF; SEVEN-UP; complementation group 7; down-and-out; seven Up; sevenup; svp-PA; svp-PB; svp-PC; svp-PE; svp-PF

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

12258737..12302785

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_169459.2 → NP_731682.1 seven up, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_731682.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P16375

Related

FBpp0082034

Conserved Domains (1) summary

cd06948
Location:45 → 280

NR_LBD_COUP-TF; Ligand binding domain of chicken ovalbumin upstream promoter transcription factors, a member of the nuclear receptor family
NM_169458.1 → NP_731681.1 seven up, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_731681.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P16376, Q8INJ0

Related

FBpp0082035, FBtr0082563

Conserved Domains (2) summary

cd06958
Location:200 → 272

NR_DBD_COUP_TF; DNA-binding domain of chicken ovalbumin upstream promoter transcription factors (COUP-TFs) is composed of two C4-type zinc fingers

cl11397
Location:307 → 452

NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
NM_001382014.1 → NP_001369011.1 seven up, isoform F [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

A0A6H2EFA9

Conserved Domains (2) summary

cd06948
Location:307 → 542

NR_LBD_COUP-TF; Ligand binding domain of chicken ovalbumin upstream promoter transcription factors, a member of the nuclear receptor family

cd06958
Location:200 → 272

NR_DBD_COUP_TF; DNA-binding domain of chicken ovalbumin upstream promoter transcription factors (COUP-TFs) is composed of two C4-type zinc fingers
NM_079601.3 → NP_524325.1 seven up, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_524325.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P16375, Q8MQJ1, Q8T8U4, Q9VGA9, Q9VGB0

Related

FBpp0082036

Conserved Domains (2) summary

cd06948
Location:307 → 542

NR_LBD_COUP-TF; Ligand binding domain of chicken ovalbumin upstream promoter transcription factors, a member of the nuclear receptor family

cd06958
Location:200 → 272

NR_DBD_COUP_TF; DNA-binding domain of chicken ovalbumin upstream promoter transcription factors (COUP-TFs) is composed of two C4-type zinc fingers
NM_001275570.1 → NP_001262499.1 seven up, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001262499.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4KFQ2

Conserved Domains (2) summary

cd06948
Location:307 → 542

NR_LBD_COUP-TF; Ligand binding domain of chicken ovalbumin upstream promoter transcription factors, a member of the nuclear receptor family

cd06958
Location:200 → 272

NR_DBD_COUP_TF; DNA-binding domain of chicken ovalbumin upstream promoter transcription factors (COUP-TFs) is composed of two C4-type zinc fingers