U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Cib2 Calcium and integrin binding family member 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37363, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Cib2provided by FlyBase
    Official Full Name
    Calcium and integrin binding family member 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0034558
    Locus tag
    Dmel_CG9236
    See related
    AllianceGenome:FB:FBgn0034558
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG9236; cib2; Dmel\CG9236
    Summary
    Predicted to enable calcium ion binding activity and magnesium ion binding activity. Involved in calcium ion homeostasis and phototransduction. Human ortholog(s) of this gene implicated in Usher syndrome type 1J and autosomal recessive nonsyndromic deafness 48. Orthologous to human CIB2 (calcium and integrin binding family member 2) and CIB3 (calcium and integrin binding family member 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Cib2 in Genome Data Viewer
    Location:
    57B4-57B4; 2-92 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (20879930..20882663)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (16767435..16770168)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Daisho2 Neighboring gene Inositol phosphate kinase 1 Neighboring gene orthopedia Neighboring gene antisense RNA:CR43160 Neighboring gene Carbonic anhydrase 15

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Alterations of the CIB2 calcium- and integrin-binding protein cause Usher syndrome type 1J and nonsyndromic deafness DFNB48. Riazuddin S, et al. Nat Genet, 2012 Nov. PMID 23023331, Free PMC Article
    2. Using Drosophila to study mechanisms of hereditary hearing loss. Li T, et al. Dis Model Mech, 2018 May 31. PMID 29853544, Free PMC Article
    3. Transgenic Drosophila lines for LexA-dependent gene and growth regulation. Chang KR, et al. G3 (Bethesda), 2022 Mar 4. PMID 35100369, Free PMC Article
    4. The Hippo pathway promotes cell survival in response to chemical stress. Di Cara F, et al. Cell Death Differ, 2015 Sep. PMID 26021298, Free PMC Article
    5. Blue light induces a neuroprotective gene expression program in Drosophila photoreceptors. Hall H, et al. BMC Neurosci, 2018 Jul 20. PMID 30029619, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in calcium ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in calcium ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phototransduction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    calcium and integrin binding family member 2
    Names
    CG9236-PB
    CIB2 ortholog
    Cib2-PB

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      20879930..20882663
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_137679.3 → NP_611523.3  calcium and integrin binding family member 2 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611523.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9W2Q5
      UniProtKB/TrEMBL
      C5WLR5
      Conserved Domains (1) summary
      COG5126
      Location:20 → 180
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W2Q5 Q9W2Q5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools