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    fz3 frizzled 3 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31023, updated on 27-Dec-2024

    Summary

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    Official Symbol
    fz3provided by FlyBase
    Official Full Name
    frizzled 3provided by FlyBase
    Primary source
    FLYBASE:FBgn0027343
    Locus tag
    Dmel_CG16785
    See related
    AllianceGenome:FB:FBgn0027343
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG16785; dfz3; dFz3; Dfz3; DFz3; Dm Fz3; Dmel\CG16785; EG:34F3.6; Fz3
    Summary
    Enables Wnt-protein binding activity. Involved in establishment or maintenance of cell polarity. Predicted to be located in membrane. Predicted to be active in extracellular space. Is expressed in several structures, including Malpighian tubule primordium; cuboidal/columnar epithelium; embryonic/larval lateral glial cell; imaginal disc; and inner photoreceptor cell. Orthologous to human FZD10 (frizzled class receptor 10) and FZD9 (frizzled class receptor 9). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See fz3 in Genome Data Viewer
    Location:
    1C4-1C4; 1-0 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (769945..784222)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (663978..678255)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene long non-coding RNA:CR44966 Neighboring gene Ribosomal protein L22 Neighboring gene twisted Neighboring gene long non-coding RNA:CR44469 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Patterning and growth control by membrane-tethered Wingless. Alexandre C, et al. Nature, 2014 Jan 9. PMID 24390349, Free PMC Article
    2. Loxl2 is a mediator of cardiac aging in Drosophila melanogaster, genetically examining the role of aging clock genes. Bouska MJ, et al. G3 (Bethesda), 2022 Jan 4. PMID 34734976, Free PMC Article
    3. The Wingless target gene Dfz3 encodes a new member of the Drosophila Frizzled family. Sivasankaran R, et al. Mech Dev, 2000 Mar 1. PMID 10704878
    4. Alternative direct stem cell derivatives defined by stem cell location and graded Wnt signalling. Reilein A, et al. Nat Cell Biol, 2017 May. PMID 28414313, Free PMC Article
    5. The USP46 deubiquitylase complex increases Wingless/Wnt signaling strength by stabilizing Arrow/LRP6. Spencer ZT, et al. Nat Commun, 2023 Oct 5. PMID 37798281, Free PMC Article

    See all (106) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    mobile_element

    • Loc: 777608-777673 mobile_element_type = transposon:INE-1{}5294

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables Wnt-protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables Wnt-protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transmembrane signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell surface receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in establishment or maintenance of cell polarity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in non-canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    frizzled 3
    Names
    CG16785-PA
    CG16785-PB
    CG16785-PC
    Dfrizzled-3
    dFrizzled3
    frizzled3
    fz3-PA
    fz3-PB
    fz3-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      769945..784222
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001297831.1 → NP_001284760.1  frizzled 3, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001284760.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O77438, Q540W1, Q9I7Z7, Q9NIU0, Q9U902, Q9W5D5
      UniProtKB/TrEMBL
      X2JC46
      Conserved Domains (2) summary
      pfam01534
      Location:226 → 519
      Frizzled; Frizzled/Smoothened family membrane region
      cl02447
      Location:37 → 159
      CRD_FZ; CRD_domain cysteine-rich domain, also known as Fz (frizzled) domain

    2. NM_080296.3 → NP_525035.2  frizzled 3, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_525035.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O77438, Q540W1, Q9I7Z7, Q9NIU0, Q9U902, Q9W5D5
      UniProtKB/TrEMBL
      X2JC46
      Related
      FBpp0070133
      Conserved Domains (2) summary
      pfam01534
      Location:226 → 519
      Frizzled; Frizzled/Smoothened family membrane region
      cl02447
      Location:37 → 159
      CRD_FZ; CRD_domain cysteine-rich domain, also known as Fz (frizzled) domain

    3. NM_001103389.2 → NP_001096859.1  frizzled 3, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001096859.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8JUT5
      Conserved Domains (4) summary
      COG0724
      Location:19 → 122
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      pfam00076
      Location:22 → 83
      RRM_1; RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
      pfam01534
      Location:291 → 584
      Frizzled; Frizzled/Smoothened family membrane region
      cl02447
      Location:138 → 224
      CRD_FZ; CRD_domain cysteine-rich domain, also known as Fz (frizzled) domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A8JUT5 A8JUT5
    O77438.2 O77438
    X2JC46 X2JC46

    Gene LinkOut

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