Megf8 Multiple EGF like domains 8 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Megf8provided by FlyBase
Official Full Name: Multiple EGF like domains 8provided by FlyBase
Primary source: FLYBASE:FBgn0031981
Locus tag: Dmel_CG7466
See related: AllianceGenome:FB:FBgn0031981
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG7466; dMegf8; Dmel\CG7466
Summary: Predicted to enable calcium ion binding activity. Is expressed in spermatozoon. Human ortholog(s) of this gene implicated in Carpenter syndrome. Orthologous to human MEGF8 (multiple EGF like domains 8). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 28D3-28D11; 2-29 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (8043471..8054326)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (8043471..8054326)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Drosophila Homolog of the Human Carpenter Syndrome Linked Gene, MEGF8, Is Required for Synapse Development and Function.
Title: Drosophila Homolog of the Human Carpenter Syndrome Linked Gene, MEGF8, Is Required for Synapse Development and Function.
This study investigated the phenotype associated with loss-of-function of CG7466, a gene that encodes the Drosophila homologue of MEGF8. This study generated three different frame-shift null mutations in CG7466 using CRISPR/Cas9 gene editing. Heterozygous flies appeared normal, but homozygous animals had disorganised denticle belts and died as 2(nd) or 3(rd) instar larvae.
Title: The Drosophila homologue of MEGF8 is essential for early development.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

mobile_element

Loc: 8051765-8051802 mobile_element_type = transposon:INE-1{}5701

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: multiple EGF like domains 8

Names: CG7466-PB; CG7466-PC; Megf8-PB; Megf8-PC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.5 Reference assembly

Range

8043471..8054326

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_135336.4 → NP_609180.3 multiple EGF like domains 8, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_609180.3

Status: REVIEWED

UniProtKB/TrEMBL

Q9VLT6

Conserved Domains (6) summary

cd00041
Location:33 → 141

CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

cd00055
Location:1304 → 1354

EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...

sd00038
Location:1760 → 1813

Kelch; KELCH repeat [structural motif]

pfam12947
Location:1186 → 1220

EGF_3; EGF domain

pfam13415
Location:1656 → 1710

Kelch_3; Galactose oxidase, central domain

pfam13418
Location:1584 → 1628

Kelch_4; Galactose oxidase, central domain
NM_001298809.1 → NP_001285738.1 multiple EGF like domains 8, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001285738.1

Status: REVIEWED

UniProtKB/TrEMBL

X2J9V1

Conserved Domains (6) summary

cd00041
Location:33 → 125

CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

cd00055
Location:1165 → 1215

EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...

sd00038
Location:1621 → 1674

Kelch; KELCH repeat [structural motif]

pfam12947
Location:1047 → 1081

EGF_3; EGF domain

pfam13415
Location:1517 → 1571

Kelch_3; Galactose oxidase, central domain

pfam13418
Location:1445 → 1489

Kelch_4; Galactose oxidase, central domain