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    su(r) suppressor of rudimentary [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31858, updated on 9-Dec-2024

    Summary

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    Official Symbol
    su(r)provided by FlyBase
    Official Full Name
    suppressor of rudimentaryprovided by FlyBase
    Primary source
    FLYBASE:FBgn0086450
    Locus tag
    Dmel_CG2194
    See related
    AllianceGenome:FB:FBgn0086450
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG2194; Dmel\CG2194; Dreg-3; pyd1; Pyd1; Reg-3; Su(r)
    Summary
    Predicted to enable NADP binding activity; dihydropyrimidine dehydrogenase (NADP+) activity; and uracil binding activity. Involved in 'de novo' pyrimidine nucleobase biosynthetic process. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Is expressed in adult head and organism. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia; dihydropyrimidine dehydrogenase deficiency; and pancreatic cancer. Orthologous to human DPYD (dihydropyrimidine dehydrogenase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See su(r) in Genome Data Viewer
    Location:
    8D1-8D1; 1-27 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (9196808..9201820, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (9090841..9095853, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene SET and MYND domain containing, arthropod-specific, member 9 Neighboring gene Odorant-binding protein 8a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. 6-Azauracil induced phenocopies of rudimentary wing mutants and their suppression by a suppressor mutant of rudimentary in Drosophila melanogaster. Stroman P, et al. Hereditas, 1973. PMID 4197330
    2. A novel circadianly expressed Drosophila melanogaster gene dependent on the period gene for its rhythmic expression. Van Gelder RN, et al. EMBO J, 1996 Apr 1. PMID 8612586, Free PMC Article
    3. Pyrimidine-sensitive drosophila wing mutants: withered (whd), tilt (tt) and dumpy (dp). Stroman P. Hereditas, 1974. PMID 4219020
    4. Evolutionary implications of the mosaic pyrimidine-biosynthetic pathway in eukaryotes. Nara T, et al. Gene, 2000 Oct 31. PMID 11080587
    5. Large-Scale Transgenic Drosophila Resource Collections for Loss- and Gain-of-Function Studies. Zirin J, et al. Genetics, 2020 Apr. PMID 32071193, Free PMC Article

    See all (46) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Clearly null, loss-of-function mutations characterize the truncated wing phenotype of su(r) mutants resulting from substitution of a highly conserved amino acid residue within dihydropyrimidine dehydrogenase.
      Title: Analysis of pyrimidine catabolism in Drosophila melanogaster using epistatic interactions with mutations of pyrimidine biosynthesis and beta-alanine metabolism.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables NADP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables dihydropyrimidine dehydrogenase (NADP+) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables dihydropyrimidine dehydrogenase (NADP+) activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables iron-sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on the CH-CH group of donors IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables uracil binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in 'de novo' pyrimidine nucleobase biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in 'de novo' pyrimidine nucleobase biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in thymine catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in uracil catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    suppressor of rudimentary
    Names
    CG2194-PC
    dihydropyrimidine dehydrogenase
    drosophila rhythmically expressed gene 3
    rhythmically expressed gene 3
    su(r)-PC
    NP_727320.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      9196808..9201820 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_167182.2 → NP_727320.1  suppressor of rudimentary [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_727320.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q4TWT4, Q9W374
      Related
      FBpp0071273
      Conserved Domains (6) summary
      PRK08318
      Location:527 → 1008
      PRK08318; dihydropyrimidine dehydrogenase subunit B; Validated
      PRK11749
      Location:55 → 507
      PRK11749; dihydropyrimidine dehydrogenase subunit A; Provisional
      cd02940
      Location:527 → 829
      DHPD_FMN; Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and ...
      pfam13187
      Location:953 → 997
      Fer4_9; 4Fe-4S dicluster domain
      pfam13450
      Location:190 → 234
      NAD_binding_8; NAD(P)-binding Rossmann-like domain
      pfam14691
      Location:58 → 170
      Fer4_20; Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q4TWT4 Q4TWT4
    Q94914 Q94914
    Q95U76 Q95U76
    Q9W374 Q9W374

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