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    Vha16-3 Vacuolar H[+] ATPase 16kD subunit 3 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 317846, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Vha16-3provided by FlyBase
    Official Full Name
    Vacuolar H[+] ATPase 16kD subunit 3provided by FlyBase
    Primary source
    FLYBASE:FBgn0028667
    Locus tag
    Dmel_CG32090
    See related
    AllianceGenome:FB:FBgn0028667
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG32090; CG7547; Dmel\CG32090; vha16-3
    Summary
    Predicted to contribute to proton-transporting ATPase activity, rotational mechanism. Predicted to be involved in proton transmembrane transport. Predicted to be part of vacuolar proton-transporting V-type ATPase, V0 domain. Predicted to be active in membrane. Is expressed in adult head. Used to study early-onset epilepsy 3. Human ortholog(s) of this gene implicated in early-onset epilepsy 3 and thyroid gland carcinoma. Orthologous to human ATP6V0C (ATPase H+ transporting V0 subunit c). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Vha16-3 in Genome Data Viewer
    Location:
    68C9-68C9; 3-36 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (11473291..11473972)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (11466391..11467072)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Fumarase 3 Neighboring gene antisense RNA:CR46049 Neighboring gene Vacuolar H[+] ATPase 16kD subunit 2 Neighboring gene charybde

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. ATP6V0C variants impair V-ATPase function causing a neurodevelopmental disorder often associated with epilepsy. Mattison KA, et al. Brain, 2023 Apr 19. PMID 36074901, Free PMC Article
    2. The multifunctional Drosophila melanogaster V-ATPase is encoded by a multigene family. Dow JA. J Bioenerg Biomembr, 1999 Feb. PMID 10340851
    3. Genome-wide survey of V-ATPase genes in Drosophila reveals a conserved renal phenotype for lethal alleles. Allan AK, et al. Physiol Genomics, 2005 Jul 14. PMID 15855386
    4. Data-mining the FlyAtlas online resource to identify core functional motifs across transporting epithelia. Chintapalli VR, et al. BMC Genomics, 2013 Jul 30. PMID 23895496, Free PMC Article
    5. Genome-scale RNAi on living-cell microarrays identifies novel regulators of Drosophila melanogaster TORC1-S6K pathway signaling. Lindquist RA, et al. Genome Res, 2011 Mar. PMID 21239477, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables proton-transporting ATPase activity, rotational mechanism IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to proton-transporting ATPase activity, rotational mechanism ISM
    Inferred from Sequence Model
    more info
    		  
    Process Evidence Code Pubs
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proton transmembrane transport ISM
    Inferred from Sequence Model
    more info
    		  
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of proton-transporting V-type ATPase, V0 domain IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of vacuolar proton-transporting V-type ATPase, V0 domain ISM
    Inferred from Sequence Model
    more info
    		  
    part_of vacuolar proton-transporting V-type ATPase, V0 domain ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    vacuolar H[+] ATPase 16kD subunit 3
    Names
    CG32090-PA
    CG32090-PB
    Vha16-3-PA
    Vha16-3-PB
    vacuolar H[+] ATPase subunit 16-3

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      11473291..11473972
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001202157.1 → NP_001189086.1  vacuolar H[+] ATPase 16kD subunit 3, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001189086.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H0RNA7, Q8IQG3
      Conserved Domains (2) summary
      TIGR01100
      Location:16 → 121
      V_ATP_synt_C; vacuolar ATP synthase 16 kDa proteolipid subunit
      cd18176
      Location:91 → 156
      ATP-synt_Vo_c_ATP6C_rpt2; V-type proton ATPase 16 kDa proteolipid subunit (ATP6C/ATP6V0C/ATP6L/ATPL) and similar proteins

    2. NM_168458.2 → NP_729706.1  vacuolar H[+] ATPase 16kD subunit 3, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729706.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H0RNA7, Q8IQG3
      Related
      FBpp0075821
      Conserved Domains (2) summary
      TIGR01100
      Location:16 → 121
      V_ATP_synt_C; vacuolar ATP synthase 16 kDa proteolipid subunit
      cd18176
      Location:91 → 156
      ATP-synt_Vo_c_ATP6C_rpt2; V-type proton ATPase 16 kDa proteolipid subunit (ATP6C/ATP6V0C/ATP6L/ATPL) and similar proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IQG3 Q8IQG3

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