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    Mettl3 Methyltransferase like 3 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42844, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mettl3provided by FlyBase
    Official Full Name
    Methyltransferase like 3provided by FlyBase
    Primary source
    FLYBASE:FBgn0039139
    Locus tag
    Dmel_CG5933
    See related
    AllianceGenome:FB:FBgn0039139
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG5933; dIME4; Dm ime4; Dmel\CG5933; ime4; Ime4; IME4; mettl3; METTL3; Mta70; MTA70
    Summary
    Enables mRNA m(6)A methyltransferase activity. Involved in female sex determination; germarium-derived female germ-line cyst encapsulation; and regulation of gene expression. Located in nucleus. Part of RNA N6-methyladenosine methyltransferase complex. Is expressed in several structures, including follicle cell; germarium; germarium region 2a; gonad; and larval central nervous system. Orthologous to human METTL3 (methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Mettl3 in Genome Data Viewer
    Location:
    95D8-95D8; 3-82 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (24032157..24034257)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (19857879..19859979)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Krueppel target at 95D Neighboring gene Like Sm 3 Neighboring gene Mitochondrial Rho Neighboring gene spastin Neighboring gene Rox8 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Ubiquitous Knockdown of Mettl3 using TRiP.GL01126 Results in Spermatid Mislocalization During Drosophila Spermatogenesis. Rowe L, et al. MicroPubl Biol, 2022. PMID 35071998, Free PMC Article
    2. Dm Ime4 depletion affects permeability barrier and Chic function in Drosophila spermatogenesis. Rockwell AL, et al. Mech Dev, 2020 Dec. PMID 33038528
    3. N(6)-adenosine methylation controls the translation of insulin mRNA. Wilinski D, et al. Nat Struct Mol Biol, 2023 Sep. PMID 37488356
    4. N6-methyladenosine dynamics in neurodevelopment and aging, and its potential role in Alzheimer's disease. Shafik AM, et al. Genome Biol, 2021 Jan 5. PMID 33402207, Free PMC Article
    5. mRNAs encoding neurodevelopmental regulators have equal N6-methyladenosine stoichiometry in Drosophila neuroblasts and neurons. Sami JD, et al. Neural Dev, 2022 Oct 15. PMID 36243726, Free PMC Article

    See all (57) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Dm Ime4 depletion affects permeability barrier and Chic function in Drosophila spermatogenesis.
      Title: Dm Ime4 depletion affects permeability barrier and Chic function in Drosophila spermatogenesis.
    2. Drosophila Inducer of MEiosis 4 (IME4) is required for Notch signaling during oogenesis.
      Title: Drosophila Inducer of MEiosis 4 (IME4) is required for Notch signaling during oogenesis.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables mRNA m(6)A methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mRNA m(6)A methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA m(6)A methyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables mRNA m(6)A methyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in RNA methylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in female sex determination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in follicle cell of egg chamber development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in germarium-derived female germ-line cyst encapsulation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mRNA modification IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of alternative mRNA splicing, via spliceosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of alternative mRNA splicing, via spliceosome IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sex determination IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in sex determination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sex-chromosome dosage compensation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in sex-chromosome dosage compensation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of RNA N6-methyladenosine methyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of RNA N6-methyladenosine methyltransferase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    methyltransferase like 3
    Names
    CG5933-PA
    Mettl3-PA
    Mta70 homologue
    inducer of MEiosis 4 homolog
    inducer of meiosis 4
    NP_651204.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      24032157..24034257
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_142947.4 → NP_651204.1  methyltransferase like 3 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651204.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VCE6
      Related
      FBpp0083917
      Conserved Domains (1) summary
      pfam05063
      Location:407 → 568
      MT-A70; MT-A70
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VCE6.1 Q9VCE6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
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