Arl6 ADP ribosylation factor-like 6 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Arl6provided by FlyBase
Official Full Name: ADP ribosylation factor-like 6provided by FlyBase
Primary source: FLYBASE:FBgn0034446
Locus tag: Dmel_CG7735
See related: AllianceGenome:FB:FBgn0034446
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: A1ZBK9; ARL6; BBS3; CG7735; Dmel\CG7735
Summary: Predicted to enable GTP binding activity and GTPase activity. Involved in cilium assembly. Predicted to be located in cilium. Predicted to be active in axoneme. Is expressed in chordotonal neurons; eo neurons; and larval antenno-maxillary sensory complex. Human ortholog(s) of this gene implicated in Bardet-Biedl syndrome; Bardet-Biedl syndrome 1; Bardet-Biedl syndrome 3; and retinitis pigmentosa 55. Orthologous to human ARL6 (ARF like GTPase 6). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (19444179..19445058)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (15331684..15332563)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

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Function	Evidence Code	Pubs
enables GTP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables GTPase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in cilium assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in cilium assembly	IEP Inferred from Expression Pattern more info	PubMed
involved_in cilium assembly	ISM Inferred from Sequence Model more info	PubMed
involved_in intracellular protein transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein localization to cilium	IBA Inferred from Biological aspect of Ancestor more info
involved_in vesicle-mediated transport	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in axoneme	IBA Inferred from Biological aspect of Ancestor more info
located_in axoneme	ISS Inferred from Sequence or Structural Similarity more info
located_in cilium	IC Inferred by Curator more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

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