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    SMC5 Structural maintenance of chromosomes 5 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 326215, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SMC5provided by FlyBase
    Official Full Name
    Structural maintenance of chromosomes 5provided by FlyBase
    Primary source
    FLYBASE:FBgn0052438
    Locus tag
    Dmel_CG32438
    See related
    AllianceGenome:FB:FBgn0052438
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    AAF51749; CG32438; CG7783; Dmel\CG32438; DmSMC5; smc5; Smc5
    Summary
    Predicted to enable ATP hydrolysis activity; damaged DNA binding activity; and single-stranded DNA binding activity. Involved in DNA damage response. Predicted to be part of Smc5-Smc6 complex. Predicted to be active in nucleus. Is expressed in organism and spermatozoon. Human ortholog(s) of this gene implicated in mosaic variegated aneuploidy syndrome. Orthologous to human SMC5 (structural maintenance of chromosomes 5). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See SMC5 in Genome Data Viewer
    Location:
    78D6-78D7; 3-47 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (21569176..21573523)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (21562276..21566623)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene CR6-interacting factor Neighboring gene mir-193 stem loop Neighboring gene ER membrane protein complex subunit 10

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. 1,6-Hexanediol Is Inducing Homologous Recombination by Releasing BLM from Assemblysomes in Drosophila melanogaster. Gombás BG, et al. Int J Mol Sci, 2024 Jan 28. PMID 38338890, Free PMC Article
    2. Early development of Drosophila embryos requires Smc5/6 function during oogenesis. Tran M, et al. Biol Open, 2016 Jul 15. PMID 27288507, Free PMC Article
    3. Structural maintenance of chromosomes (SMC) proteins, a family of conserved ATPases. Harvey SH, et al. Genome Biol, 2002. PMID 11864377, Free PMC Article
    4. Cervantes and Quijote protect heterochromatin from aberrant recombination and lead the way to the nuclear periphery. Ryu T, et al. Nucleus, 2016 Sep 2. PMID 27673416, Free PMC Article
    5. Conserved disruptions in the predicted coiled-coil domains of eukaryotic SMC complexes: implications for structure and function. Beasley M, et al. Genome Res, 2002 Aug. PMID 12176928, Free PMC Article

    See all (46) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables ATP hydrolysis activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables damaged DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables single-stranded DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in DNA repair ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in double-strand break repair via homologous recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in double-strand break repair via homologous recombination IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of Smc5-Smc6 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Smc5-Smc6 complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of Smc5-Smc6 complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    structural maintenance of chromosomes 5
    Names
    CG32438-PE
    CG32438-PF
    CG32438-PG
    CG32438-PH
    SMC5-PE
    SMC5-PF
    SMC5-PG
    SMC5-PH
    Smc5

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      21569176..21573523
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_168924.4 → NP_730660.3  structural maintenance of chromosomes 5, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730660.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KTV9, Q8T386
      Conserved Domains (3) summary
      cd03277
      Location:886 → 992
      ABC_SMC5_euk; ATP-binding cassette domain of eukaryotic SMC5 proteins
      COG1196
      Location:22 → 978
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cl12013
      Location:187 → 339
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    2. NM_206419.3 → NP_996141.2  structural maintenance of chromosomes 5, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996141.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7YU66, Q8IPT2
      Conserved Domains (3) summary
      cd03277
      Location:919 → 1025
      ABC_SMC5_euk; ATP-binding cassette domain of eukaryotic SMC5 proteins
      COG1196
      Location:22 → 1011
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cl03075
      Location:212 → 316
      GrpE; nucleotide exchange factor GrpE

    3. NM_001275247.1 → NP_001262176.1  structural maintenance of chromosomes 5, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262176.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PGC9, Q7YU66
      Conserved Domains (3) summary
      cd03277
      Location:910 → 1016
      ABC_SMC5_euk; ATP-binding cassette domain of eukaryotic SMC5 proteins
      COG1196
      Location:22 → 1002
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cl03075
      Location:212 → 316
      GrpE; nucleotide exchange factor GrpE

    4. NM_141077.5 → NP_649334.3  structural maintenance of chromosomes 5, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649334.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8T386, Q9VP12
      Conserved Domains (3) summary
      cd03277
      Location:877 → 983
      ABC_SMC5_euk; ATP-binding cassette domain of eukaryotic SMC5 proteins
      COG1196
      Location:22 → 969
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cl12013
      Location:187 → 339
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PGC9 M9PGC9
    Q7KTV9 Q7KTV9
    Q7YU66 Q7YU66
    Q8IPT2 Q8IPT2
    Q8T386 Q8T386
    Q95S77 Q95S77
    Q9VP12 Q9VP12

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