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    Tia1 TIA1 cytotoxic granule-associated RNA binding protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 312510, updated on 4-Jan-2025

    Summary

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    Official Symbol
    Tia1provided by RGD
    Official Full Name
    TIA1 cytotoxic granule-associated RNA binding proteinprovided by RGD
    Primary source
    RGD:1305742
    See related
    EnsemblRapid:ENSRNOG00000016813 AllianceGenome:RGD:1305742
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable mRNA 3'-UTR AU-rich region binding activity. Involved in positive regulation of epithelial cell apoptotic process. Located in cytoplasmic stress granule. Part of ribonucleoprotein complex. Biomarker of transient cerebral ischemia. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis type 26. Orthologous to human TIA1 (TIA1 cytotoxic granule associated RNA binding protein). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in Thymus (RPKM 172.0), Brain (RPKM 95.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tia1 in Genome Data Viewer
    Location:
    4q34
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (120410180..120440676)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (118852765..118883252)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (118207845..118238246)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene prenylcysteine oxidase 1 Neighboring gene transfer RNA glycine (anticodon CCC) 4 Neighboring gene similar to human chromosome 2 open reading frame 42 Neighboring gene uncharacterized LOC134486603 Neighboring gene uncharacterized LOC134486604

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Prolonged translation arrest in reperfused hippocampal cornu Ammonis 1 is mediated by stress granules. Kayali F, et al. Neuroscience, 2005. PMID 16055272
    2. Polyamines inhibit the assembly of stress granules in normal intestinal epithelial cells regulating apoptosis. Zou T, et al. Am J Physiol Cell Physiol, 2012 Jul 1. PMID 22555848, Free PMC Article
    3. The apoptosis-promoting factor TIA-1 is a regulator of alternative pre-mRNA splicing. Förch P, et al. Mol Cell, 2000 Nov. PMID 11106748
    4. Identification of the sequence determinants mediating the nucleo-cytoplasmic shuttling of TIAR and TIA-1 RNA-binding proteins. Zhang T, et al. J Cell Sci, 2005 Dec 1. PMID 16278295
    5. TIA-1 is a translational silencer that selectively regulates the expression of TNF-alpha. Piecyk M, et al. EMBO J, 2000 Aug 1. PMID 10921895, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TIAR regulates the relative expression of TIA-1 isoforms.
      Title: Two isoforms of the T-cell intracellular antigen 1 (TIA-1) splicing factor display distinct splicing regulation activities. Control of TIA-1 isoform ratio by TIA-1-related protein.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables mRNA 3'-UTR AU-rich region binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables mRNA 3'-UTR binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within negative regulation of cytokine production ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of translation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of translation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of epithelial cell apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization to cytoplasmic stress granule ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of alternative mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in stress granule assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasmic stress granule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasmic stress granule ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear stress granule ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of ribonucleoprotein complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cytotoxic granule associated RNA binding protein TIA1
    Names
    cytotoxic granule-associated RNA binding protein 1
    nucleolysin TIA-1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012096.1 → NP_001012096.1  cytotoxic granule associated RNA binding protein TIA1

      Status: PROVISIONAL

      Source sequence(s)
      BC087064
      UniProtKB/TrEMBL
      F7FKD5, Q5PQR7
      Related
      ENSRNOP00000094527.1, ENSRNOT00000107832.2
      Conserved Domains (4) summary
      cd12618
      Location:94 → 173
      RRM2_TIA1; RNA recognition motif 2 in nucleolysin TIA-1 isoform p40 (p40-TIA-1) and similar proteins
      cd12621
      Location:203 → 276
      RRM3_TIA1; RNA recognition motif 3 in nucleolysin TIA-1 isoform p40 (p40-TIA-1) and similar proteins
      TIGR01661
      Location:6 → 269
      ELAV_HUD_SF; ELAV/HuD family splicing factor
      cl17169
      Location:8 → 81
      RRM_SF; RNA recognition motif (RRM) superfamily

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      120410180..120440676
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006236828.4 → XP_006236890.1  cytotoxic granule associated RNA binding protein TIA1 isoform X3

      UniProtKB/TrEMBL
      A0A8I6AKZ8
      Related
      ENSRNOP00000096950.2, ENSRNOT00000110929.2
      Conserved Domains (4) summary
      cd12618
      Location:106 → 185
      RRM2_TIA1; RNA recognition motif 2 in nucleolysin TIA-1 isoform p40 (p40-TIA-1) and similar proteins
      cd12620
      Location:215 → 287
      RRM3_TIAR; RNA recognition motif 3 in nucleolysin TIAR and similar proteins
      TIGR01661
      Location:6 → 281
      ELAV_HUD_SF; ELAV/HuD family splicing factor
      cl17169
      Location:8 → 82
      RRM_SF; RNA recognition motif (RRM) superfamily

    2. XM_006236830.5 → XP_006236892.1  cytotoxic granule associated RNA binding protein TIA1 isoform X7

      UniProtKB/TrEMBL
      F7FKD5
      Related
      ENSRNOP00000023102.5, ENSRNOT00000023103.6
      Conserved Domains (4) summary
      cd12618
      Location:95 → 174
      RRM2_TIA1; RNA recognition motif 2 in nucleolysin TIA-1 isoform p40 (p40-TIA-1) and similar proteins
      cd12621
      Location:204 → 277
      RRM3_TIA1; RNA recognition motif 3 in nucleolysin TIA-1 isoform p40 (p40-TIA-1) and similar proteins
      TIGR01661
      Location:6 → 270
      ELAV_HUD_SF; ELAV/HuD family splicing factor
      cl17169
      Location:8 → 82
      RRM_SF; RNA recognition motif (RRM) superfamily

    3. XM_063286065.1 → XP_063142135.1  cytotoxic granule associated RNA binding protein TIA1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AKZ8

    4. XM_063286067.1 → XP_063142137.1  cytotoxic granule associated RNA binding protein TIA1 isoform X4

      UniProtKB/TrEMBL
      F7FKD5

    5. XM_039107613.2 → XP_038963541.1  cytotoxic granule associated RNA binding protein TIA1 isoform X10

      UniProtKB/TrEMBL
      A0A8I6ASW3
      Conserved Domains (1) summary
      cl17169
      Location:8 → 82
      RRM_SF; RNA recognition motif (RRM) superfamily

    6. XM_006236829.5 → XP_006236891.1  cytotoxic granule associated RNA binding protein TIA1 isoform X5

      UniProtKB/TrEMBL
      A0A8I6AKZ8, A6IAW7
      Conserved Domains (4) summary
      cd12618
      Location:105 → 184
      RRM2_TIA1; RNA recognition motif 2 in nucleolysin TIA-1 isoform p40 (p40-TIA-1) and similar proteins
      cd12620
      Location:214 → 286
      RRM3_TIAR; RNA recognition motif 3 in nucleolysin TIAR and similar proteins
      TIGR01661
      Location:6 → 280
      ELAV_HUD_SF; ELAV/HuD family splicing factor
      cl17169
      Location:8 → 81
      RRM_SF; RNA recognition motif (RRM) superfamily

    7. XM_063286066.1 → XP_063142136.1  cytotoxic granule associated RNA binding protein TIA1 isoform X2

      UniProtKB/TrEMBL
      A0A8I6AKZ8

    8. XM_063286068.1 → XP_063142138.1  cytotoxic granule associated RNA binding protein TIA1 isoform X6

      UniProtKB/TrEMBL
      F7FKD5

    9. XM_063286069.1 → XP_063142139.1  cytotoxic granule associated RNA binding protein TIA1 isoform X8

    10. XM_063286071.1 → XP_063142141.1  cytotoxic granule associated RNA binding protein TIA1 isoform X9

    11. XM_063286070.1 → XP_063142140.1  cytotoxic granule associated RNA binding protein TIA1 isoform X9

    12. XM_063286072.1 → XP_063142142.1  cytotoxic granule associated RNA binding protein TIA1 isoform X9

    RNA

    1. XR_005503216.2 RNA Sequence

    2. XR_005503217.2 RNA Sequence

    3. XR_005503219.2 RNA Sequence

    4. XR_005503220.2 RNA Sequence

    5. XR_005503221.2 RNA Sequence

    6. XR_005503218.2 RNA Sequence

      Related
      ENSRNOT00000112790.2
    Nucleotide Protein Strain
    Heading Accession and Version

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