Gda guanine deaminase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Gdaprovided by RGD
Official Full Name: guanine deaminaseprovided by RGD
Primary source: RGD:621617
See related: EnsemblRapid:ENSRNOG00000018282 AllianceGenome:RGD:621617
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Cypin
Summary: Enables guanine deaminase activity. Involved in positive regulation of microtubule polymerization. Is active in postsynaptic cytosol and presynaptic cytosol. Orthologous to human GDA (guanine deaminase). [provided by Alliance of Genome Resources, Jan 2025]
Expression: Biased expression in Lung (RPKM 1007.4), Spleen (RPKM 602.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q51

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (228333401..228408901, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (218903045..218982360, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (238982542..239057663, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Overexpression of cypin alters dendrite branching and effects mean spike rate over time.
Title: Overexpression of cypin alters dendrite morphology, single neuron activity, and network properties via distinct mechanisms.
Identification of several histidines and aspartic acid residues of cypin responsible for zinc binding.
Title: Structural characterization of the zinc binding domain in cytosolic PSD-95 interactor (cypin): Role of zinc binding in guanine deamination and dendrite branching.
Cypin protein acts downstream of the small GTPase RhoA protein to regulate dendrite branching in hippocampal neurons.
Title: RhoA regulates dendrite branching in hippocampal neurons by decreasing cypin protein levels.
the experiments on guanase and nedasin in rat organs performed in this study are considered to have important implications in the investigation of their physiological significance
Title: A histochemical and immunohistochemical investigation of guanase and nedasin in rat and human tissues.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D1Rat299 (e-PCR), detects polymorphism
- UniSTS:227111

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables guanine deaminase activity	IBA Inferred from Biological aspect of Ancestor more info
enables guanine deaminase activity	IDA Inferred from Direct Assay more info	PubMed
enables guanine deaminase activity	IEA Inferred from Electronic Annotation more info
enables guanine deaminase activity	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in GMP catabolic process	IEA Inferred from Electronic Annotation more info
involved_in GMP catabolic process	ISO Inferred from Sequence Orthology more info
involved_in allantoin metabolic process	IEA Inferred from Electronic Annotation more info
involved_in allantoin metabolic process	ISO Inferred from Sequence Orthology more info
involved_in amide catabolic process	IEA Inferred from Electronic Annotation more info
involved_in amide catabolic process	ISO Inferred from Sequence Orthology more info
involved_in dGMP catabolic process	IEA Inferred from Electronic Annotation more info
involved_in dGMP catabolic process	ISO Inferred from Sequence Orthology more info
involved_in deoxyguanosine catabolic process	IEA Inferred from Electronic Annotation more info
involved_in deoxyguanosine catabolic process	ISO Inferred from Sequence Orthology more info
involved_in guanine catabolic process	IEA Inferred from Electronic Annotation more info
involved_in guanine catabolic process	ISO Inferred from Sequence Orthology more info
involved_in guanine metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of microtubule polymerization	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in postsynapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in postsynaptic cytosol	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic cytosol	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in presynaptic cytosol	IDA Inferred from Direct Assay more info	PubMed
is_active_in presynaptic cytosol	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: guanine deaminase

Names: GAH; guanase; guanine aminase; guanine aminohydrolase

NP_113964.2

EC 3.5.4.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031776.2 → NP_113964.2 guanine deaminase

Status: PROVISIONAL

Source sequence(s)

AF245172

UniProtKB/Swiss-Prot

Q9WTT6

UniProtKB/TrEMBL

Q9JKB7

Related

ENSRNOP00000024775.6, ENSRNOT00000024775.7

Conserved Domains (1) summary

cd01303
Location:13 → 444

GDEase; Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and ...