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    COX5B Cytochrome c oxidase subunit 5B [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33918, updated on 27-Dec-2024

    Summary

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    Official Symbol
    COX5Bprovided by FlyBase
    Official Full Name
    Cytochrome c oxidase subunit 5Bprovided by FlyBase
    Primary source
    FLYBASE:FBgn0031830
    Locus tag
    Dmel_CG11015
    See related
    AllianceGenome:FB:FBgn0031830
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-EST:Posey143; anon-WO0118547.187; BcDNA:RH49324; CcO Vb; CG11015; CoVb; cox5B; Cox5b; COXB; COXVb; Dmel\CG11015; Q9VMB9; Vb
    Summary
    Predicted to be involved in mitochondrial electron transport, cytochrome c to oxygen. Located in mitochondrial inner membrane. Part of respiratory chain complex IV. Is expressed in several structures, including adult head; embryonic/larval midgut primordium; ganglia; gut section; and larval muscle cell. Used to study cytochrome-c oxidase deficiency disease. Orthologous to human COX5B (cytochrome c oxidase subunit 5B). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See COX5B in Genome Data Viewer
    Location:
    26E3-26E3; 2-21 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (6557800..6559308)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (6557800..6559308)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44776 Neighboring gene Intraflagellar transport 52 Neighboring gene Cytochrome c oxidase subunit 5B-like Neighboring gene tRNA methyltransferase 6 non-catalytic subunit Neighboring gene Equilibrative nucleoside transporter 2 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A genetically encoded biosensor for visualising hypoxia responses in vivo. Misra T, et al. Biol Open, 2017 Feb 15. PMID 28011628, Free PMC Article
    2. Decrease in cytochrome c oxidase reserve capacity diminishes robustness of Drosophila melanogaster and shortens lifespan. Klichko V, et al. Biochem J, 2014 Apr 1. PMID 24444354
    3. Practical Recommendations for the Use of the GeneSwitch Gal4 System to Knock-Down Genes in Drosophila melanogaster. Scialo F, et al. PLoS One, 2016. PMID 27570965, Free PMC Article
    4. Cytochrome c oxidase loses catalytic activity and structural integrity during the aging process in Drosophila melanogaster. Ren JC, et al. Biochem Biophys Res Commun, 2010 Oct 8. PMID 20833144, Free PMC Article
    5. Mitochondrial electron transport chain dysfunction during development does not extend lifespan in Drosophila melanogaster. Rera M, et al. Mech Ageing Dev, 2010 Feb. PMID 20096722

    See all (65) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in mitochondrial electron transport, cytochrome c to oxygen IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial electron transport, cytochrome c to oxygen IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrial electron transport, cytochrome c to oxygen ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial envelope IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of respiratory chain complex IV IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of respiratory chain complex IV IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of respiratory chain complex IV ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    cytochrome c oxidase subunit 5B
    Names
    CG11015-PA
    CG11015-PB
    COX5B-PA
    COX5B-PB
    cytochrome c oxidase Vb
    cytochrome c oxidase polypeptide Vb
    cytochrome c oxidase subunit Vb
    subunit Vb
    succinate-CoA ligase subunit beta

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      6557800..6559308
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_135202.2 → NP_609046.1  cytochrome c oxidase subunit 5B, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609046.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VMB9
      Related
      FBpp0078918, FBtr0079288
      Conserved Domains (1) summary
      cd00924
      Location:25 → 120
      Cyt_c_Oxidase_Vb; Cytochrome c oxidase subunit Vb. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of ...

    2. NM_001298749.1 → NP_001285678.1  cytochrome c oxidase subunit 5B, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285678.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VMB9
      Conserved Domains (1) summary
      cd00924
      Location:25 → 120
      Cyt_c_Oxidase_Vb; Cytochrome c oxidase subunit Vb. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q86NN8 Q86NN8
    Q9VMB9 Q9VMB9

    Gene LinkOut

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