TSG101 Tumor susceptibility gene 101 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: TSG101provided by FlyBase
Official Full Name: Tumor susceptibility gene 101provided by FlyBase
Primary source: FLYBASE:FBgn0036666
Locus tag: Dmel_CG9712
See related: AllianceGenome:FB:FBgn0036666
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: burs; CG9712; Dmel\CG9712; DmTSG101; dTsg101; dTSg101; dVps23; ept; Ept; ESCRT-I; Tsg1-1; tsg101; Tsg101; vps23; Vps23
Summary: Predicted to enable ubiquitin binding activity. Involved in several processes, including multivesicular body assembly; negative regulation of imaginal disc growth; and neuron remodeling. Part of ESCRT I complex. Is expressed in several structures, including adult head; anterior endoderm; cuboidal/columnar epithelium; embryonic/larval garland cell; and garland cell primordium. Used to study cancer and carcinoma. Human ortholog(s) of this gene implicated in breast cancer; breast carcinoma; cervix carcinoma; endometrial adenocarcinoma; and prostate cancer. Orthologous to human TSG101 (tumor susceptibility 101). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (16842294..16844585)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (16835394..16837685)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin binding	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in endosome to lysosome transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in liquid clearance, open tracheal system	HMP more info	PubMed
involved_in maintenance of apical/basal cell polarity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in multivesicular body assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of imaginal disc growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron remodeling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein modification process	IEA Inferred from Electronic Annotation more info
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in receptor-mediated endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in symbiont entry into host cell	HMP more info	PubMed
involved_in terminal branching, open tracheal system	HMP more info	PubMed

Component	Evidence Code	Pubs
part_of ESCRT I complex	IBA Inferred from Biological aspect of Ancestor more info
part_of ESCRT I complex	IDA Inferred from Direct Assay more info	PubMed
part_of ESCRT I complex	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Names: CG9712-PA; TSG101-PA; erupted; tumor suppressor protein 101; tumor susceptibility Gene-101; tumor susceptibility gene 101 ortholog; tumour susceptibility gene 101

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