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    Iyd Iodotyrosine deiodinase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39242, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Iydprovided by FlyBase
    Official Full Name
    Iodotyrosine deiodinaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0286980
    Locus tag
    Dmel_CG46438
    See related
    AllianceGenome:FB:FBgn0286980
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    cdt; CG46438; CG6279; CG6279-PB; Dmel\CG46438; dmIYD; IYD
    Old locus tag
    Dmel_CG6279
    Summary
    Enables FMN binding activity and iodotyrosine deiodinase activity. Involved in positive regulation of fertilization. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Iyd in Genome Data Viewer
    Location:
    68A6-68A6; 3-34 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (11093371..11096245, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (11086471..11089345, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Nucleolar complex protein 1 Neighboring gene JIL-1 kinase Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Inverted repeat binding protein 18 kDa Neighboring gene beta-Amyloid precursor protein binding protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The importance of a halotyrosine dehalogenase for Drosophila fertility. Phatarphekar A, et al. J Biol Chem, 2018 Jun 29. PMID 29764939, Free PMC Article
    2. Misregulation of bromotyrosine compromises fertility in male Drosophila. Su Q, et al. Proc Natl Acad Sci U S A, 2024 May 21. PMID 38748578, Free PMC Article
    3. Functional analysis of iodotyrosine deiodinase from drosophila melanogaster. Phatarphekar A, et al. Protein Sci, 2016 Dec. PMID 27643701, Free PMC Article
    4. Genetic and phenotypic analysis of alleles of the Drosophila chromosomal JIL-1 kinase reveals a functional requirement at multiple developmental stages. Zhang W, et al. Genetics, 2003 Nov. PMID 14668387, Free PMC Article
    5. A global in vivo Drosophila RNAi screen identifies NOT3 as a conserved regulator of heart function. Neely GG, et al. Cell, 2010 Apr 2. PMID 20371351, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables FMN binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables iodotyrosine deiodinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables oxidoreductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of fertilization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in tyrosine metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    iodotyrosine deiodinase
    Names
    CG46438-PB
    CG46438-PC
    Iyd-PB
    Iyd-PC
    condet
    NP_001163414.1
    NP_001369045.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      11093371..11096245 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001382155.1 → NP_001369045.1  iodotyrosine deiodinase, isoform C [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      E1JIB2
      UniProtKB/TrEMBL
      Q8T3Q0
      Conserved Domains (1) summary
      cd02144
      Location:89 → 283
      iodotyrosine_dehalogenase; iodotyrosine dehalogenase

    2. NM_001169943.1 → NP_001163414.1  iodotyrosine deiodinase, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163414.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      E1JIB2
      UniProtKB/TrEMBL
      Q8T3Q0
      Conserved Domains (1) summary
      cd02144
      Location:89 → 283
      iodotyrosine_dehalogenase; iodotyrosine dehalogenase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    E1JIB2.1 E1JIB2

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