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    ATbp (A+T)-stretch binding protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 5740592, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ATbpprovided by FlyBase
    Official Full Name
    (A+T)-stretch binding proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0039946
    Locus tag
    Dmel_CG17172
    See related
    AllianceGenome:FB:FBgn0039946
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    ATBP; CG17172; CG40145; Dmel\CG17172
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Is expressed in dorsal pharyngeal muscle cell; embryonic anal pad; embryonic hindgut; embryonic/larval midgut; and organism. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See ATbp in Genome Data Viewer
    Location:
    20F4-20F4; 1-66 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (23106003..23108331)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) XHet NW_001848859.1 (84821..87149)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene suppressor of forked Neighboring gene pseudo Neighboring gene 28S ribosomal RNA pseudogene:CR45853 Neighboring gene mir-10404-3 stem loop

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification and characterization of a Drosophila homologue of ATBP. Aozasa N, et al. Insect Mol Biol, 2002 Feb. PMID 11841500
    2. A 5.9-kb tandem repeat at the euchromatin-heterochromatin boundary of the X chromosome of Drosophila melanogaster. O'Hare K, et al. Mol Genet Genomics, 2002 Jul. PMID 12172804
    3. New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk. Lu Y, et al. Nat Commun, 2016 Feb 1. PMID 26833246, Free PMC Article
    4. A Comprehensive Drosophila melanogaster Transcription Factor Interactome. Shokri L, et al. Cell Rep, 2019 Apr 16. PMID 30995488, Free PMC Article
    5. A large-scale, in vivo transcription factor screen defines bivalent chromatin as a key property of regulatory factors mediating Drosophila wing development. Schertel C, et al. Genome Res, 2015 Apr. PMID 25568052, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    • Annotated by Drosophila Heterochromatin Genome Project, Lawrence Berkeley National Lab, http://www.dhgp.org

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    (A+T)-stretch binding protein
    Names
    ATbp-PB
    CG17172-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      23106003..23108331
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001111011.3 → NP_001104481.2  (A+T)-stretch binding protein [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001104481.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q86P48
      Conserved Domains (1) summary
      sd00017
      Location:323 → 345
      ZF_C2H2; C2H2 Zn finger [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q86P48.2 Q86P48

    Gene LinkOut

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