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    CG6418 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39218, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG6418provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0036104
    Locus tag
    Dmel_CG6418
    See related
    AllianceGenome:FB:FBgn0036104
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    cg6418; Dmel\CG6418; DmRH27
    Summary
    Predicted to enable RNA binding activity and RNA helicase activity. Predicted to be involved in protein localization. Predicted to be active in nucleus. Is expressed in several structures, including ganglia; larval nervous system; pole plasm; and tracheal primordium. Orthologous to human DDX42 (DEAD-box helicase 42). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG6418 in Genome Data Viewer
    Location:
    67F1-67F1; 3-33 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (10876315..10879037, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (10869415..10872137, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45246 Neighboring gene tonalli Neighboring gene long non-coding RNA:CR45169 Neighboring gene Biogenesis of lysosome-related organelles complex 1, subunit 4 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Drosophila trithorax group gene tonalli (tna) interacts genetically with the Brahma remodeling complex and encodes an SP-RING finger protein. Gutiérrez L, et al. Development, 2003 Jan. PMID 12466201
    2. DDX56 Binds to Chikungunya Virus RNA To Control Infection. Taschuk F, et al. mBio, 2020 Oct 27. PMID 33109765, Free PMC Article
    3. Stem-loop recognition by DDX17 facilitates miRNA processing and antiviral defense. Moy RH, et al. Cell, 2014 Aug 14. PMID 25126784, Free PMC Article
    4. Evolution of intron/exon structure of DEAD helicase family genes in Arabidopsis, Caenorhabditis, and Drosophila. Boudet N, et al. Genome Res, 2001 Dec. PMID 11731501, Free PMC Article
    5. RNA silencing in the antiviral innate immune defence--role of DEAD-box RNA helicases. Ulvila J, et al. Scand J Immunol, 2010 Mar. PMID 20415780

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables RNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA helicase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein localization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG6418-PB
    NP_648413.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      10876315..10879037 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_140156.3 → NP_648413.1  uncharacterized protein Dmel_CG6418 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648413.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VTC1
      Related
      FBpp0076003
      Conserved Domains (3) summary
      smart00487
      Location:284 → 489
      DEXDc; DEAD-like helicases superfamily
      cd00268
      Location:271 → 475
      DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...
      pfam00271
      Location:504 → 609
      Helicase_C; Helicase conserved C-terminal domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VTC1 Q9VTC1

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