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    tgy twiggy [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32896, updated on 9-Dec-2024

    Summary

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    Official Symbol
    tgyprovided by FlyBase
    Official Full Name
    twiggyprovided by FlyBase
    Primary source
    FLYBASE:FBgn0030984
    Locus tag
    Dmel_CG7440
    See related
    AllianceGenome:FB:FBgn0030984
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG7440; dC1GalT5; Dmel\CG7440; Tgy
    Summary
    Predicted to enable glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity. Predicted to be located in membrane. Is expressed in several structures, including gastric caecum; gut section; larval nervous system; nurse cell; and testis. Orthologous to human C1GALT1 (core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See tgy in Genome Data Viewer
    Location:
    18A3-18A3; 1-62 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (19125003..19127316, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (19019036..19021349, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45503 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45711 Neighboring gene Odorant-binding protein 18a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Requirement for a core 1 galactosyltransferase in the Drosophila nervous system. Lin YR, et al. Dev Dyn, 2008 Dec. PMID 18985719, Free PMC Article
    2. Functional dissection of the ash2 and ash1 transcriptomes provides insights into the transcriptional basis of wing phenotypes and reveals conserved protein interactions. Beltran S, et al. Genome Biol, 2007. PMID 17466076, Free PMC Article
    3. Phenotype-based clustering of glycosylation-related genes by RNAi-mediated gene silencing. Yamamoto-Hino M, et al. Genes Cells, 2015 Jun. PMID 25940448, Free PMC Article
    4. Cold acclimation wholly reorganizes the Drosophila melanogaster transcriptome and metabolome. MacMillan HA, et al. Sci Rep, 2016 Jun 30. PMID 27357258, Free PMC Article
    5. CRISPR-based modular assembly of a UAS-cDNA/ORF plasmid library for more than 5500 Drosophila genes conserved in humans. Wei P, et al. Genome Res, 2020 Jan. PMID 31722958, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    twiggy
    Names
    CG7440-PC
    CG7440-PE
    tgy-PC
    tgy-PE
    NP_001285425.1
    NP_573349.4

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      19125003..19127316 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298496.1 → NP_001285425.1  twiggy, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285425.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VWM1
      Conserved Domains (1) summary
      cl21608
      Location:103 → 270
      Galactosyl_T; Galactosyltransferase

    2. NM_133121.5 → NP_573349.4  twiggy, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_573349.4

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VWM1
      Conserved Domains (1) summary
      cl21608
      Location:103 → 270
      Galactosyl_T; Galactosyltransferase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8SZV7 Q8SZV7
    Q9VWM1 Q9VWM1

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