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    Nrk Neurospecific receptor kinase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36445, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Nrkprovided by FlyBase
    Official Full Name
    Neurospecific receptor kinaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0020391
    Locus tag
    Dmel_CG4007
    See related
    AllianceGenome:FB:FBgn0020391
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO2004063362.79; CG4007; Dmel\CG4007; DmHD-434; Dnrk; DNRK; HD-434; l(2)k14301; nrk; nrtk_dros; ROR2
    Summary
    Enables protein tyrosine kinase activity. Involved in muscle cell cellular homeostasis; neuron development; and signal transduction. Predicted to be part of receptor complex. Predicted to be active in plasma membrane. Is expressed in neurogenic region; peripheral nervous system; and presumptive embryonic/larval central nervous system. Human ortholog(s) of this gene implicated in congenital myasthenic syndrome 9 and fetal akinesia deformation sequence syndrome 1. Orthologous to human MUSK (muscle associated receptor tyrosine kinase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See Nrk in Genome Data Viewer
    Location:
    49F4-49F4; 2-68 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (13160063..13163484)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (9047568..9050989)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Activated Cdc42 kinase-like Neighboring gene Tripeptidyl-peptidase II Neighboring gene NADH dehydrogenase (ubiquinone) MWFE subunit Neighboring gene uncharacterized protein Neighboring gene Glial Lazarillo Neighboring gene antisense RNA:CR45142 Neighboring gene Serine palmitoyltransferase subunit I

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A novel Drosophila receptor tyrosine kinase expressed specifically in the nervous system. Unique structural features and implication in developmental signaling. Oishi I, et al. J Biol Chem, 1997 May 2. PMID 9115253
    2. Identification of a Frizzled-like cysteine rich domain in the extracellular region of developmental receptor tyrosine kinases. Saldanha J, et al. Protein Sci, 1998 Jul. PMID 9684897, Free PMC Article
    3. Identification of a Frizzled-like cysteine rich domain in the extracellular region of developmental receptor tyrosine kinases. Saldanha J, et al. Protein Sci, 1998 Aug. PMID 10082384, Free PMC Article
    4. An allele of sequoia dominantly enhances a trio mutant phenotype to influence Drosophila larval behavior. Dean KE, et al. PLoS One, 2013. PMID 24376789, Free PMC Article
    5. Genetic, molecular and physiological basis of variation in Drosophila gut immunocompetence. Bou Sleiman MS, et al. Nat Commun, 2015 Jul 27. PMID 26213329, Free PMC Article

    See all (60) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables Wnt-protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein tyrosine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane receptor protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane receptor protein tyrosine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell surface receptor protein tyrosine kinase signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell surface receptor protein tyrosine kinase signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in multicellular organism development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in muscle cell cellular homeostasis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in muscle cell cellular homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in photoreceptor cell axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in rhabdomere development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in signal transduction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    part_of receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    neurospecific receptor kinase
    Names
    CG4007-PA
    Nrk-PA
    drosophila neurospecific receptor kinase
    neuronal receptor kinase
    neurospecific receptor tyrosine kinase
    neurotrophic receptor kinase
    neurotropic receptor kinase
    NP_477255.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      13160063..13163484
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_057907.4 → NP_477255.1  neurospecific receptor kinase [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B3LF77, O02001, O96391, Q9TYH9, Q9V6K3
      Related
      FBpp0086841
      Conserved Domains (4) summary
      cd05050
      Location:435 → 713
      PTKc_Musk; Catalytic domain of the Protein Tyrosine Kinase, Muscle-specific kinase
      smart00130
      Location:217 → 299
      KR; Kringle domain
      pfam07714
      Location:441 → 707
      Pkinase_Tyr; Protein tyrosine kinase
      cl02447
      Location:67 → 212
      CRD_FZ; CRD_domain cysteine-rich domain, also known as Fz (frizzled) domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9V6K3.2 Q9V6K3

    Gene LinkOut

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