klu klumpfuss [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: kluprovided by FlyBase
Official Full Name: klumpfussprovided by FlyBase
Primary source: FLYBASE:FBgn0013469
Locus tag: Dmel_CG12296
See related: AllianceGenome:FB:FBgn0013469
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG12296; Dmel\CG12296; Klu; KLU; l(3)09036; l(3)10052; P09036
Summary: Enables DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; and cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including generation of neurons; larval feeding behavior; and neuronal stem cell population maintenance. Located in nucleus. Is expressed in several structures, including apterous-expressing neuron of the lateral cluster of the thorax; cuboidal/columnar epithelium; imaginal disc; neuroblasts; and pigment cell. Human ortholog(s) of this gene implicated in pancreatitis. Orthologous to human SPINK1 (serine peptidase inhibitor Kazal type 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 68A1-68A1; 3-34 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (10981171..11009188, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (10974271..11002288, complement)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

a role for the transcription factor Klumpfuss (Klu) in restricting the fate of enteroblasts (EBs) in the Drosophila intestine, is reported.
Title: The WT1-like transcription factor Klumpfuss maintains lineage commitment of enterocyte progenitors in the Drosophila intestine.
Klu does not lie downstream of the Notch pathway in asymmetric cell division context.
Title: A new role of Klumpfuss in establishing cell fate during the GMC asymmetric cell division.
the Brat-dependent mechanism extinguishes the function of the self-renewal factor Klu in the presumptive intermediate progenitor cell by attenuating Arm activity, balancing stem cell maintenance and progenitor cell specification.
Title: Brain tumor specifies intermediate progenitor cell identity by attenuating β-catenin/Armadillo activity.
Klu is expressed specifically in the postmitotic Ap4/FMRFa neuron, promoting its differentiation through the initiation of BMP signaling
Title: Klumpfuss controls FMRFamide expression by enabling BMP signaling within the NB5-6 lineage.
FACS purification and transcriptome analysis of drosophila neural stem cells reveals a role for Klumpfuss in self-renewal.
Title: FACS purification and transcriptome analysis of drosophila neural stem cells reveals a role for Klumpfuss in self-renewal.
multiple mechanisms converge to exert precise control of klu and distinguish a progenitor cell from its sibling stem cell during asymmetric neuroblast division
Title: klumpfuss distinguishes stem cells from progenitor cells during asymmetric neuroblast division.
show that the products of the genes klumpfuss, nab and castor play important roles in their specification via a genetic cascade
Title: A genetic cascade involving klumpfuss, nab and castor specifies the abdominal leucokinergic neurons in the Drosophila CNS.
Klumpfuss is a zinc finger transcription factor that acts as a repressor of transcription to promote sensory organ precursor cell formation and regulates proneural proteins.
Title: Klumpfuss is involved in the determination of sensory organ precursors in Drosophila.
klumpfuss is required and differentially expressed in the cells that choose the life or death cell fate during normal cell fate selection in Drosophila retina
Title: klumpfuss regulates cell death in the Drosophila retina.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables sequence-specific DNA binding	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in R7 cell differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in larval feeding behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in neuroblast development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neurogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuronal stem cell population maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of compound eye retinal cell programmed cell death	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of neuroblast proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of neuroblast proliferation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of neuroblast proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of stem cell division	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in sensory organ precursor cell fate determination	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: klumpfuss

Names: CG12296-PA; CG12296-PB; CG12296-PC; CG12296-PD; klu-PA; klu-PB; klu-PC; klu-PD; klumphuss

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

10981171..11009188 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001300095.1 → NP_001287024.1 klumpfuss, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001287024.1

Status: REVIEWED

UniProtKB/TrEMBL

Q5BIH1, Q9VTD3

Conserved Domains (4) summary

sd00017
Location:628 → 648

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:626 → 648

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:640 → 665

zf-H2C2_2; Zinc-finger double domain

cl19417
Location:182 → 248

FYDLN_acid; Protein of unknown function (FYDLN_acid)
NM_001274762.1 → NP_001261691.1 klumpfuss, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001261691.1

Status: REVIEWED

UniProtKB/TrEMBL

Q5BIH1, Q9VTD3

Conserved Domains (4) summary

sd00017
Location:628 → 648

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:626 → 648

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:640 → 665

zf-H2C2_2; Zinc-finger double domain

cl19417
Location:182 → 248

FYDLN_acid; Protein of unknown function (FYDLN_acid)
NM_057714.4 → NP_477062.1 klumpfuss, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_477062.1

Status: REVIEWED

UniProtKB/TrEMBL

Q5BIH1, Q9VTD3

Related

FBpp0075976

Conserved Domains (4) summary

sd00017
Location:628 → 648

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:626 → 648

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:640 → 665

zf-H2C2_2; Zinc-finger double domain

cl19417
Location:182 → 248

FYDLN_acid; Protein of unknown function (FYDLN_acid)
NM_001274761.1 → NP_001261690.1 klumpfuss, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001261690.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PF84, Q5BIH1

Conserved Domains (5) summary

COG5048
Location:607 → 687

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:628 → 648

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:626 → 648

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:640 → 665

zf-H2C2_2; Zinc-finger double domain

cl19417
Location:182 → 248

FYDLN_acid; Protein of unknown function (FYDLN_acid)