Ubx Ultrabithorax [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Ubxprovided by FlyBase
Official Full Name: Ultrabithoraxprovided by FlyBase
Primary source: FLYBASE:FBgn0003944
Locus tag: Dmel_CG10388
See related: AllianceGenome:FB:FBgn0003944
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: abx; abx/bx; bx; BX-C; bxd; bxd/pbx; bxd[D]; bxl; Bxl; bx[D]; Cbx; CG10388; Dm Ubx; Dmel\CG10388; DmUbx; DUbx; Hm; l(3)89Eb; pbx; Pbx; Uab; ubx; UBx; UBX; Ubx1b; Ubx[[Drosophila]]
Summary: Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; protein domain specific binding activity; and transcription coregulator binding activity. Involved in several processes, including cell fate specification; imaginal disc-derived appendage development; and regulation of DNA-templated transcription. Located in nucleus and polytene chromosome band. Part of protein-DNA complex and transcription repressor complex. Is expressed in several structures, including anterior-posterior subdivision of organism; developmental compartment; imaginal disc; neuromere; and visceral mesoderm derivative. Used to study leukemia. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 89D6-89D9; 3-59 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (16656623..16734426, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (12482345..12560148, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Wing hearts in four-winged Ultrabithorax-mutant flies-the role of Hox genes in wing heart specification.
Title: Wing hearts in four-winged Ultrabithorax-mutant flies-the role of Hox genes in wing heart specification.
Novel Antennapedia and Ultrabithorax trimeric complexes with TBP and Exd regulate transcription.
Title: Novel Antennapedia and Ultrabithorax trimeric complexes with TBP and Exd regulate transcription.
The Variable CTCF Site from Drosophila melanogaster Ubx Gene is Redundant and Has no Insulator Activity.
Title: The Variable CTCF Site from Drosophila melanogaster Ubx Gene is Redundant and Has no Insulator Activity.
The Hox Transcription Factor Ubx Ensures Somatic Myogenesis by Suppressing the Mesodermal Master Regulator Twist.
Title: The Hox Transcription Factor Ubx Ensures Somatic Myogenesis by Suppressing the Mesodermal Master Regulator Twist.
Ubx-Collier signaling cascade maintains blood progenitors in the posterior lobes of the Drosophila larval lymph gland.
Title: Ubx-Collier signaling cascade maintains blood progenitors in the posterior lobes of the Drosophila larval lymph gland.
Hox dosage contributes to flight appendage morphology in Drosophila.
Title: Hox dosage contributes to flight appendage morphology in Drosophila.
Control of tissue morphogenesis by the HOX gene Ultrabithorax.
Title: Control of tissue morphogenesis by the HOX gene Ultrabithorax.
Through the combination of gene expression, optical imaging, and quantitative behavioral approaches, we provide evidence that miR-iab4 exerts its effects on adult self-righting behavior in part through repression of the Hox gene Ultrabithorax (Ubx) in a specific set of adult motor neurons, the NB2-3/lin15 neurons.
Title: A Single MicroRNA-Hox Gene Module Controls Equivalent Movements in Biomechanically Distinct Forms of Drosophila.
This study demonstrates that Ubx stabilizes lineage choice by suppressing the multipotency encoded in the genome via its interaction with Pho.
Title: The Hox transcription factor Ubx stabilizes lineage commitment by suppressing cellular plasticity in Drosophila.
Transcription sites of the full svb cis-regulatory region inserted into a different chromosome colocalized with the svb locus, increasing Ubx concentration, the transcriptional output of svb, and partially rescuing the phenotype.
Title: Multi-enhancer transcriptional hubs confer phenotypic robustness.

Submit: New GeneRIF Correction See all GeneRIFs (68)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dm1698 (e-PCR)
- UniSTS:40052

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables cis-regulatory region sequence-specific DNA binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables sequence-specific DNA binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables transcription coregulator binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in anterior Malpighian tubule development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in anterior/posterior pattern specification	IBA Inferred from Biological aspect of Ancestor more info
involved_in anterior/posterior pattern specification	TAS Traceable Author Statement more info	PubMed
involved_in cell fate determination	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cell fate determination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dorsal vessel aortic cell fate commitment	TAS Traceable Author Statement more info	PubMed
involved_in endoderm formation	TAS Traceable Author Statement more info	PubMed
involved_in haltere development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heart development	IEP Inferred from Expression Pattern more info	PubMed
involved_in heart development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc-derived leg morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mesodermal cell fate specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in midgut development	TAS Traceable Author Statement more info	PubMed
involved_in muscle cell fate specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in open tracheal system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of muscle organ development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell fate specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of imaginal disc growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in somatic muscle development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in specification of animal organ identity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in specification of segmental identity, thorax	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in specification of segmental identity, thorax	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in polytene chromosome band	IDA Inferred from Direct Assay more info	PubMed
part_of protein-DNA complex	IMP Inferred from Mutant Phenotype more info	PubMed
part_of transcription regulator complex	IMP Inferred from Mutant Phenotype more info	PubMed
part_of transcription regulator complex	NAS Non-traceable Author Statement more info	PubMed
part_of transcription repressor complex	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: ultrabithorax

Names: CG10388-PA; CG10388-PB; CG10388-PC; CG10388-PD; CG10388-PE; CG10388-PF; Ubx-PA; Ubx-PB; Ubx-PC; Ubx-PD; Ubx-PE; Ubx-PF; anterobithorax; bithorax; bithorax complex; bithoraxoid; contrabithorax; haltere mimic; postbithorax; ultabithorax; ultarbithorax; ultraabdominal