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    Cht12 Chitinase 12 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 246535, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Cht12provided by FlyBase
    Official Full Name
    Chitinase 12provided by FlyBase
    Primary source
    FLYBASE:FBgn0050293
    Locus tag
    Dmel_CG30293
    See related
    AllianceGenome:FB:FBgn0050293
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:AT18578; CG30293; Cht; cht12; DmCht12; Dmel\CG30293; NEST:bs09g08; NEST:bs28h08; NEST:bs33a06
    Summary
    Predicted to enable chitinase activity. Involved in several processes, including chitin-based cuticle development; ecdysis, chitin-based cuticle; and regulation of tube architecture, open tracheal system. Predicted to be active in extracellular region. Human ortholog(s) of this gene implicated in asthma. Orthologous to human CHIA (chitinase acidic). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Cht12 in Genome Data Viewer
    Location:
    57B16-57B16; 2-92 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (21063178..21064986, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (16950683..16952491, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene capping protein alpha Neighboring gene uncharacterized protein Neighboring gene mitochondrial ribosomal protein L54 Neighboring gene Chitinase 8 Neighboring gene Chitinase 4 Neighboring gene antisense RNA:CR44703 Neighboring gene Chitinase 9

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cross-phenotype association tests uncover genes mediating nutrient response in Drosophila. Nelson CS, et al. BMC Genomics, 2016 Nov 4. PMID 27809764, Free PMC Article
    2. Computational identification of novel chitinase-like proteins in the Drosophila melanogaster genome. Zhu Q, et al. Bioinformatics, 2004 Jan 22. PMID 14734306
    3. Chitinase family GH18: evolutionary insights from the genomic history of a diverse protein family. Funkhouser JD, et al. BMC Evol Biol, 2007 Jun 26. PMID 17594485, Free PMC Article
    4. The biology of insect chitinases and their roles at chitinous cuticles. Rabadiya D, et al. Insect Biochem Mol Biol, 2024 Feb. PMID 38184175
    5. Manual curation and phylogenetic analysis of chitinase family genes in the Asian citrus psyllid, Diaphorina citri. Shippy TD, et al. GigaByte, 2022. PMID 36824529, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables chitin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables chitinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    NOT enables chitinase activity IKR
    Inferred from Key Residues
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chitin catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chitin-based cuticle development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ecdysis, chitin-based cuticle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of tube architecture, open tracheal system IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in wound healing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in extracellular region IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    chitinase 12
    Names
    CG30293-PA
    Cht12-PA
    NP_726022.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      21063178..21064986 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_166420.2 → NP_726022.1  chitinase 12 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726022.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MLW8, Q8T443
      Related
      FBpp0071473
      Conserved Domains (3) summary
      smart00494
      Location:394 → 438
      ChtBD2; Chitin-binding domain type 2
      pfam00704
      Location:47 → 355
      Glyco_hydro_18; Glycosyl hydrolases family 18
      cl10447
      Location:25 → 375
      GH18_chitinase-like; The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8MLW8 Q8MLW8
    Q8T443 Q8T443

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