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    CG5539 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37766, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG5539provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0034907
    Locus tag
    Dmel_CG5539
    See related
    AllianceGenome:FB:FBgn0034907
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG5539
    Summary
    Predicted to enable microtubule binding activity. Predicted to be involved in endoplasmic reticulum tubular network organization. Predicted to be active in cytoplasmic microtubule; endoplasmic reticulum membrane; and endoplasmic reticulum tubular network. Is expressed in adult head. Orthologous to human REEP4 (receptor accessory protein 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG5539 in Genome Data Viewer
    Location:
    60A1-60A2; 2-105 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (23804811..23806144)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (19692334..19693667)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene sol narae Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Structure specific recognition protein Neighboring gene uncharacterized protein Neighboring gene NTF2-related export protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Modeling of axonal endoplasmic reticulum network by spastic paraplegia proteins. Yalçın B, et al. Elife, 2017 Jul 25. PMID 28742022, Free PMC Article
    2. Quantitative proteomics and phosphoproteomics reveal insights into mechanisms of ocnus function in Drosophila testis development. Zheng Y, et al. BMC Genomics, 2023 May 26. PMID 37237333, Free PMC Article
    3. The genetic basis for variation in olfactory behavior in Drosophila melanogaster. Arya GH, et al. Chem Senses, 2015 May. PMID 25687947, Free PMC Article
    4. Next-generation large-scale binary protein interaction network for Drosophila melanogaster. Tang HW, et al. Nat Commun, 2023 Apr 15. PMID 37061542, Free PMC Article
    5. CRISPR-based modular assembly of a UAS-cDNA/ORF plasmid library for more than 5500 Drosophila genes conserved in humans. Wei P, et al. Genome Res, 2020 Jan. PMID 31722958, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in endoplasmic reticulum tubular network organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasmic microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in endoplasmic reticulum tubular network IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG5539-PA
    CG5539-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      23804811..23806144
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001299853.1 → NP_001286782.1  uncharacterized protein Dmel_CG5539, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286782.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8T3S2, Q9W1J5
      Conserved Domains (1) summary
      pfam03134
      Location:8 → 94
      TB2_DP1_HVA22; TB2/DP1, HVA22 family

    2. NM_137987.2 → NP_611831.2  uncharacterized protein Dmel_CG5539, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611831.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8T3S2, Q9W1J5
      Related
      FBpp0072032, FBtr0072123
      Conserved Domains (1) summary
      pfam03134
      Location:8 → 94
      TB2_DP1_HVA22; TB2/DP1, HVA22 family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8T3S2 Q8T3S2
    Q9W1J5 Q9W1J5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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