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    ZnT63C Zinc transporter 63C [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38407, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ZnT63Cprovided by FlyBase
    Official Full Name
    Zinc transporter 63Cprovided by FlyBase
    Primary source
    FLYBASE:FBgn0035432
    Locus tag
    Dmel_CG17723
    See related
    AllianceGenome:FB:FBgn0035432
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    cg17723; CG17723; Dmel\CG17723; dZnT1; dZNT1; dZnT63C; dZNT63C; ZnT1; ZnT63; ZNT63C
    Summary
    Enables zinc efflux transmembrane transporter activity. Involved in several processes, including detoxification of zinc ion; intracellular zinc ion homeostasis; and renal zinc excretion. Located in apical plasma membrane and basolateral plasma membrane. Is expressed in several structures, including adult head; amnioserosa primordium; anlage in statu nascendi; embryonic/larval midgut primordium; and epithelium. Human ortholog(s) of this gene implicated in hypermanganesemia with dystonia 1. Orthologous to human SLC30A1 (solute carrier family 30 member 1) and SLC30A10 (solute carrier family 30 member 10). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See ZnT63C in Genome Data Viewer
    Location:
    63C6-63D1; 3-7 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (3303708..3314009)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (3303708..3314009)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene mir-955 stem loop Neighboring gene uncharacterized protein Neighboring gene Drosomycin-like 2 Neighboring gene Drosomycin-like 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila ZnT1 is essential in the intestine for dietary zinc absorption. Wang Z, et al. Biochem Biophys Res Commun, 2020 Dec 17. PMID 33012507
    2. Enhancers display constrained sequence flexibility and context-specific modulation of motif function. Reiter F, et al. Genome Res, 2023 Mar. PMID 36941077, Free PMC Article
    3. Zinc binding directly regulates tau toxicity independent of tau hyperphosphorylation. Huang Y, et al. Cell Rep, 2014 Aug 7. PMID 25066125, Free PMC Article
    4. Local and systemic effects of targeted zinc redistribution in Drosophila neuronal and gastrointestinal tissues. Richards CD, et al. Biometals, 2015 Dec. PMID 26411574
    5. Zinc supplement greatly improves the condition of parkin mutant Drosophila. Saini N, et al. Biol Chem, 2010 May. PMID 20302514

    See all (79) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Drosophila ZnT1 is essential in the intestine for dietary zinc absorption.
      Title: Drosophila ZnT1 is essential in the intestine for dietary zinc absorption.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables monoatomic cation transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc efflux transmembrane transporter activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables zinc ion transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion transmembrane transporter activity IC
    Inferred by Curator
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in detoxification of zinc ion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in detoxification of zinc ion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular zinc ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular zinc ion homeostasis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in intracellular zinc ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in monoatomic cation transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in renal zinc excretion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in zinc ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in zinc ion transmembrane transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in basolateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    zinc transporter 63C
    Names
    CG17723-PA
    CG17723-PB
    CG17723-PC
    CG17723-PD
    CG17723-PE
    CG17723-PF
    CG17723-PG
    ZnT63C-PA
    ZnT63C-PB
    ZnT63C-PC
    ZnT63C-PD
    ZnT63C-PE
    ZnT63C-PF
    ZnT63C-PG

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      3303708..3314009
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_168015.2 → NP_728856.1  zinc transporter 63C, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728856.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K3K5
      Related
      FBpp0072919
      Conserved Domains (2) summary
      COG1230
      Location:10 → 339
      CzcD; Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]
      pfam01545
      Location:21 → 260
      Cation_efflux; Cation efflux family

    2. NM_168017.2 → NP_728858.1  zinc transporter 63C, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728858.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K3K5
      Related
      FBpp0072921
      Conserved Domains (2) summary
      COG1230
      Location:10 → 339
      CzcD; Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]
      pfam01545
      Location:21 → 260
      Cation_efflux; Cation efflux family

    3. NM_168016.2 → NP_728857.1  zinc transporter 63C, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728857.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K3K5
      Related
      FBpp0072920
      Conserved Domains (2) summary
      COG1230
      Location:10 → 339
      CzcD; Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]
      pfam01545
      Location:21 → 260
      Cation_efflux; Cation efflux family

    4. NM_001274435.1 → NP_001261364.1  zinc transporter 63C, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261364.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PEG6
      Conserved Domains (2) summary
      COG1230
      Location:10 → 339
      CzcD; Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]
      pfam01545
      Location:21 → 260
      Cation_efflux; Cation efflux family

    5. NM_139544.3 → NP_647801.1  zinc transporter 63C, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_647801.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K3K5
      Related
      FBpp0072918
      Conserved Domains (2) summary
      COG1230
      Location:10 → 339
      CzcD; Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]
      pfam01545
      Location:21 → 260
      Cation_efflux; Cation efflux family

    6. NM_168018.2 → NP_728859.1  zinc transporter 63C, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728859.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K3K5
      Related
      FBpp0072922
      Conserved Domains (2) summary
      COG1230
      Location:10 → 339
      CzcD; Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]
      pfam01545
      Location:21 → 260
      Cation_efflux; Cation efflux family

    7. NM_001274436.1 → NP_001261365.1  zinc transporter 63C, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261365.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K3K5
      Conserved Domains (2) summary
      COG1230
      Location:10 → 339
      CzcD; Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]
      pfam01545
      Location:21 → 260
      Cation_efflux; Cation efflux family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PEG6 M9PEG6
    Q7K3K5 Q7K3K5

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