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    Sec3 Secretory 3 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39940, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Sec3provided by FlyBase
    Official Full Name
    Secretory 3provided by FlyBase
    Primary source
    FLYBASE:FBgn0266669
    Locus tag
    Dmel_CG3885
    See related
    AllianceGenome:FB:FBgn0266669
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG3885; Dmel\CG3885; sec3
    Summary
    Predicted to enable phosphatidylinositol-4,5-bisphosphate binding activity. Predicted to be involved in Golgi to plasma membrane transport and exocytosis. Part of exocyst. Is expressed in adult head. Orthologous to human EXOC1 (exocyst complex component 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Sec3 in Genome Data Viewer
    Location:
    74B2-74B3; 3-45 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (17421787..17425217, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (17414887..17418317, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene bloated tubules Neighboring gene long non-coding RNA:noe Neighboring gene Cytochrome c oxidase subunit 7B Neighboring gene RNA polymerase III subunit G

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Exocyst Component Sec3 Controls Egg Chamber Development Through Notch During Drosophila Oogenesis. Wan P, et al. Front Physiol, 2019. PMID 30984026, Free PMC Article
    2. Guidance receptor promotes the asymmetric distribution of exocyst and recycling endosome during collective cell migration. Wan P, et al. Development, 2013 Dec. PMID 24198275
    3. PI(4,5)P2 controls slit diaphragm formation and endocytosis in Drosophila nephrocytes. Gass MM, et al. Cell Mol Life Sci, 2022 Apr 18. PMID 35437696, Free PMC Article
    4. Exocyst-mediated apical Wg secretion activates signaling in the Drosophila wing epithelium. Chaudhary V, et al. PLoS Genet, 2019 Sep. PMID 31527874, Free PMC Article
    5. The exocyst subunit Sec15 is critical for proper synaptic development and function at the Drosophila NMJ. Kang CJ, et al. Mol Cell Neurosci, 2024 Mar. PMID 38086519

    See all (49) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables phosphatidylinositol-4,5-bisphosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol-4,5-bisphosphate binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in Golgi to plasma membrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in exocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of exocyst IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of exocyst IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of exocyst IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    secretory 3
    Names
    CG3885-PA
    Sec3 ortholog
    Sec3-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      17421787..17425217 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_140719.4 → NP_648976.2  secretory 3 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648976.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q95R79, Q9VVG4
      UniProtKB/TrEMBL
      V5P0Q7
      Related
      FBpp0074993
      Conserved Domains (2) summary
      cd14683
      Location:9 → 126
      PH-EXOC1; PH-like domain of Exocyst complex component 1
      pfam09763
      Location:200 → 866
      Sec3_C; Exocyst complex component Sec3
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VVG4.2 Q9VVG4

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