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    AspRS-m Aspartyl-tRNA synthetase, mitochondrial [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 326155, updated on 9-Dec-2024

    Summary

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    Official Symbol
    AspRS-mprovided by FlyBase
    Official Full Name
    Aspartyl-tRNA synthetase, mitochondrialprovided by FlyBase
    Primary source
    FLYBASE:FBgn0051739
    Locus tag
    Dmel_CG31739
    See related
    AllianceGenome:FB:FBgn0051739
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG17938; CG31739; Dmel\CG31739
    Summary
    Predicted to enable aspartate-tRNA ligase activity. Predicted to be involved in aspartyl-tRNA aminoacylation. Predicted to be located in cytoplasm. Predicted to be active in mitochondrion. Is expressed in adult head; embryonic brain; larval ventral nerve cord; and organism. Orthologous to human DARS2 (aspartyl-tRNA synthetase 2, mitochondrial). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See AspRS-m in Genome Data Viewer
    Location:
    36B2-36B2; 2-53 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (16827078..16832093)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (16827078..16832093)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene midway Neighboring gene Chromosome segregation 1 Neighboring gene uncharacterized protein Neighboring gene Neprilysin-like 9 Neighboring gene Sarcolamban B Neighboring gene Sarcolamban A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Conserved regulation of cardiac calcium uptake by peptides encoded in small open reading frames. Magny EG, et al. Science, 2013 Sep 6. PMID 23970561
    2. Cyclin E-dependent protein kinase activity regulates niche retention of Drosophila ovarian follicle stem cells. Wang ZA, et al. Proc Natl Acad Sci U S A, 2009 Dec 22. PMID 19966222, Free PMC Article
    3. The aminoacyl-tRNA synthetases of Drosophila melanogaster. Lu J, et al. Fly (Austin), 2015. PMID 26761199, Free PMC Article
    4. Drosophila follicle stem cells are regulated by proliferation and niche adhesion as well as mitochondria and ROS. Wang ZA, et al. Nat Commun, 2012 Apr 3. PMID 22473013, Free PMC Article
    5. Pilot RNAi Screen in Drosophila Neural Stem Cell Lineages to Identify Novel Tumor Suppressor Genes Involved in Asymmetric Cell Division. Manzanero-Ortiz S, et al. Int J Mol Sci, 2021 Oct 20. PMID 34768763, Free PMC Article

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables aminoacyl-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables aspartate-tRNA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables aspartate-tRNA ligase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in aspartyl-tRNA aminoacylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in aspartyl-tRNA aminoacylation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in tRNA aminoacylation for protein translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Aspartyl-tRNA synthetase, mitochondrial
    Names
    AspRS-m-PA
    AspRS-m-PB
    AspRS-m-PD
    CG31739-PA
    CG31739-PB
    CG31739-PD
    NP_001260519.1
    NP_001260520.2
    NP_724018.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      16827078..16832093
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_165196.2 → NP_724018.1  Aspartyl-tRNA synthetase, mitochondrial, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724018.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VJH2, Q9VJH3
      Related
      FBpp0080475
      Conserved Domains (4) summary
      PRK00476
      Location:405 → 988
      aspS; aspartyl-tRNA synthetase; Validated
      cd00777
      Location:542 → 960
      AspRS_core; Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the ...
      cd04317
      Location:405 → 538
      EcAspRS_like_N; EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND) ...
      cl09930
      Location:91 → 246
      RPA_2b-aaRSs_OBF_like; Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold.

    2. NM_001273590.1 → NP_001260519.1  Aspartyl-tRNA synthetase, mitochondrial, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260519.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VJH2, Q9VJH3
      Conserved Domains (4) summary
      PRK00476
      Location:405 → 988
      aspS; aspartyl-tRNA synthetase; Validated
      cd00777
      Location:542 → 960
      AspRS_core; Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the ...
      cd04317
      Location:405 → 538
      EcAspRS_like_N; EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND) ...
      cl09930
      Location:91 → 246
      RPA_2b-aaRSs_OBF_like; Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold.

    3. NM_001273591.1 → NP_001260520.2  Aspartyl-tRNA synthetase, mitochondrial, isoform D [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PDL2
      Conserved Domains (3) summary
      PRK00476
      Location:462 → 1045
      aspS; aspartyl-tRNA synthetase; Validated
      cd04317
      Location:291 → 410
      EcAspRS_like_N; N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND) Helicobacter pylori ...
      cl09930
      Location:148 → 303
      RPA_2b-aaRSs_OBF_like; Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PDL2 M9PDL2
    Q9VJH2 Q9VJH2

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