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    Cadps Calcium-dependent secretion activator [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 49968, updated on 17-Dec-2024

    Summary

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    Official Symbol
    Cadpsprovided by FlyBase
    Official Full Name
    Calcium-dependent secretion activatorprovided by FlyBase
    Primary source
    FLYBASE:FBgn0053653
    Locus tag
    Dmel_CG33653
    See related
    AllianceGenome:FB:FBgn0053653
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:GH07283; cap; caps; Caps; CAPS; CG17881; CG18026; CG33653; CG40477; dcaps; dCAPS; Dmel\CG33653; l(4)102Fb; SDCAP
    Summary
    Predicted to enable calcium ion binding activity. Involved in glutamatergic synaptic transmission and synaptic vesicle exocytosis. Located in synapse. Is expressed in several structures, including NMJ bouton; adult head; ganglia; larval somatic muscle cell; and neuroblasts. Orthologous to human CADPS (calcium dependent secretion activator) and CADPS2 (calcium dependent secretion activator 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Cadps in Genome Data Viewer
    Location:
    102F8-102F8; 4-0 cM
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 4 NC_004353.4 (1230837..1271759)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 4 NC_004353.3 (1234563..1275485)

    Chromosome 4 - NC_004353.4Genomic Context describing neighboring genes Neighboring gene mitf Neighboring gene Dual-specificity tyrosine phosphorylation-regulated kinase 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. RNA editing regulates transposon-mediated heterochromatic gene silencing. Savva YA, et al. Nat Commun, 2013. PMID 24201902, Free PMC Article
    2. Whole arm inversions of chromosome 4 in Drosophila species. Podemski L, et al. Chromosoma, 2001 Aug. PMID 11534822
    3. Heterochromatin protein 1a is required for an open chromatin structure. Cryderman DE, et al. Transcription, 2011 Mar. PMID 21468237, Free PMC Article
    4. Proteome-Wide Analysis of ADAR-Mediated Messenger RNA Editing during Fruit Fly Ontogeny. Kliuchnikova AA, et al. J Proteome Res, 2020 Oct 2. PMID 32866021
    5. Drosophila CAPS is an essential gene that regulates dense-core vesicle release and synaptic vesicle fusion. Renden R, et al. Neuron, 2001 Aug 16. PMID 11516399

    See all (56) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Contributes to the instructive role of bridge-cells in embryonic trachea.
      Title: Distinct functions of the leucine-rich repeat transmembrane proteins capricious and tartan in the Drosophila tracheal morphogenesis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    mobile_element

    • Loc: 1234105-1234445 mobile_element_type = transposon:INE-1{}3979
    • Loc: 1241115-1241458 mobile_element_type = transposon:INE-1{}3980
    • Loc: 1247285-1247633 mobile_element_type = transposon:INE-1{}5457
    • Loc: 1247634-1248167 mobile_element_type = transposon:INE-1{}5476
    • Loc: 1249348-1250418 mobile_element_type = transposon:INE-1{}3991
    • Loc: 1252868-1253001 mobile_element_type = transposon:INE-1{}3993
    • Loc: 1256227-1260813 mobile_element_type = transposon:F{}1572
    • Loc: 1257060-1258095 mobile_element_type = transposon:1360{}4082
    • Loc: 1258096-1259175 mobile_element_type = transposon:1360{}1571
    • Loc: 1261516-1261787 mobile_element_type = transposon:INE-1{}3995
    • Loc: 1263507-1263580 mobile_element_type = transposon:INE-1{}3997
    • Loc: 1265878-1266322 mobile_element_type = transposon:Cr1a{}5477
    • Loc: 1266559-1267388 mobile_element_type = transposon:Quasimodo{}4050
    • Loc: 1270253-1270622 mobile_element_type = transposon:INE-1{}4007

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables calcium ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in dense core granule exocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in neurotransmitter secretion NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of calcium ion-dependent exocytosis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in synaptic transmission, glutamatergic IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in synaptic vesicle exocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in synaptic vesicle exocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in synaptic vesicle exocytosis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in vesicle-mediated transport NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in synaptic vesicle NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Calcium-dependent secretion activator
    Names
    CG33653-PA
    CG33653-PB
    CG33653-PD
    CG33653-PE
    CG33653-PF
    Cadps-PA
    Cadps-PB
    Cadps-PD
    Cadps-PE
    Cadps-PF
    Calcium-activated protein for secretion
    calcium activated protein for secretion

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004353.4 Reference assembly

      Range
      1230837..1271759
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001031858.2 → NP_001027029.2  Calcium-dependent secretion activator, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001027029.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      H9XVQ4, H9XVQ5, Q4AB01, Q5LJP1, Q8IM88, Q8IM89, Q8MT21, Q9NHE5, Q9Y135
      Conserved Domains (3) summary
      cd01234
      Location:585 → 711
      PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
      pfam00169
      Location:593 → 699
      PH; PH domain
      pfam06292
      Location:904 → 997
      DUF1041; Domain of Unknown Function (DUF1041)

    2. NM_001258510.2 → NP_001245439.1  Calcium-dependent secretion activator, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245439.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      H9XVQ4, H9XVQ5, Q4AB01, Q5LJP1, Q8IM88, Q8IM89, Q8MT21, Q9NHE5, Q9Y135
      Conserved Domains (3) summary
      cd01234
      Location:585 → 711
      PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
      pfam00169
      Location:593 → 699
      PH; PH domain
      pfam06292
      Location:904 → 1066
      DUF1041; Domain of Unknown Function (DUF1041)

    3. NM_001258511.2 → NP_001245440.1  Calcium-dependent secretion activator, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245440.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      H9XVQ4, H9XVQ5, Q4AB01, Q5LJP1, Q8IM88, Q8IM89, Q8MT21, Q9NHE5, Q9Y135
      Conserved Domains (3) summary
      cd01234
      Location:585 → 711
      PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
      pfam00169
      Location:593 → 699
      PH; PH domain
      pfam06292
      Location:903 → 1065
      DUF1041; Domain of Unknown Function (DUF1041)

    4. NM_001031859.2 → NP_001027030.1  Calcium-dependent secretion activator, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001027030.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      H9XVQ4, H9XVQ5, Q4AB01, Q5LJP1, Q8IM88, Q8IM89, Q8MT21, Q9NHE5, Q9Y135
      Conserved Domains (3) summary
      cd01234
      Location:565 → 691
      PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
      pfam00169
      Location:573 → 679
      PH; PH domain
      pfam06292
      Location:884 → 977
      DUF1041; Domain of Unknown Function (DUF1041)

    5. NM_001031860.2 → NP_001027031.1  Calcium-dependent secretion activator, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001027031.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      H9XVQ4, H9XVQ5, Q4AB01, Q5LJP1, Q8IM88, Q8IM89, Q8MT21, Q9NHE5, Q9Y135
      Conserved Domains (3) summary
      cd01234
      Location:580 → 706
      PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
      pfam00169
      Location:588 → 694
      PH; PH domain
      pfam06292
      Location:899 → 1061
      DUF1041; Domain of Unknown Function (DUF1041)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9NHE5.3 Q9NHE5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.