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    Gtpx Glutathione peroxidase homolog with thioredoxin peroxidase activity [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38413, updated on 9-Dec-2024

    Summary

    Official Symbol
    Gtpxprovided by FlyBase
    Official Full Name
    Glutathione peroxidase homolog with thioredoxin peroxidase activityprovided by FlyBase
    Primary source
    FLYBASE:FBgn0035438
    Locus tag
    Dmel_CG12013
    See related
    AllianceGenome:FB:FBgn0035438
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0257455.17; CG12013; dGPX4; Dmel\CG12013; DmGpx; DmGPx; DmPHGPx; Gpx; GPx; GTPx; Gtpx-1; GTPx-1; PGTPx; phgpx; phGpx; PHGPx; Tpx1
    Summary
    Enables thioredoxin-dependent peroxiredoxin activity. Involved in intestinal stem cell homeostasis; response to endoplasmic reticulum stress; and response to oxidative stress. Located in Golgi apparatus. Is expressed in several structures, including adult head; adult heart; amnioserosa; embryonic/larval fat body; and germline cell. Human ortholog(s) of this gene implicated in colorectal adenocarcinoma; colorectal cancer; and spondylometaphyseal dysplasia Sedaghatian type. Orthologous to human GPX4 (glutathione peroxidase 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See Gtpx in Genome Data Viewer
    Location:
    63D1-63D1; 3-8 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (3326265..3328626)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (3326265..3328626)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Phosphatidylinositol glycan anchor biosynthesis class C Neighboring gene uncharacterized protein Neighboring gene Dolichyl-phosphate mannosyltransferase subunit 2 Neighboring gene Striatin interacting protein Neighboring gene long non-coding RNA:CR45380 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

    Preferred Names
    glutathione peroxidase homolog with thioredoxin peroxidase activity
    Names
    CG12013-PA
    CG12013-PC
    CG12013-PD
    Gtpx-PA
    Gtpx-PC
    Gtpx-PD
    PHGPx
    PHGPx with glutathione peroxidase activity
    glutathione peroxidase
    glutathione peroxidase I
    phospholipid hydroperoxide glutathione peroxidase
    NP_728868.1
    NP_728869.1
    NP_728870.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      3326265..3328626
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_168024.2NP_728868.1  glutathione peroxidase homolog with thioredoxin peroxidase activity, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728868.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IRD4
      Related
      FBpp0072930
      Conserved Domains (1) summary
      cd00340
      Location:41194
      GSH_Peroxidase; Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per ...
    2. NM_168025.2NP_728869.1  glutathione peroxidase homolog with thioredoxin peroxidase activity, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728869.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86NS7, Q8IRD3
      Related
      FBpp0072932
      Conserved Domains (1) summary
      cd00340
      Location:81234
      GSH_Peroxidase; Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per ...
    3. NM_168026.2NP_728870.1  glutathione peroxidase homolog with thioredoxin peroxidase activity, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728870.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VZQ8
      Related
      FBpp0072931
      Conserved Domains (1) summary
      cd00340
      Location:12165
      GSH_Peroxidase; Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per ...