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    simj simjang [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39212, updated on 9-Dec-2024

    Summary

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    Official Symbol
    simjprovided by FlyBase
    Official Full Name
    simjangprovided by FlyBase
    Primary source
    FLYBASE:FBgn0010762
    Locus tag
    Dmel_CG32067
    See related
    AllianceGenome:FB:FBgn0010762
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0118547.361; CG32067; CG7983; CG8000; Dmel\CG32067; dp66; l(3)01814; l(3)j4A5; l(3)rN672; p66; p66/68; p66/68-like; SIMJ
    Summary
    Involved in several processes, including cardiac cell fate specification; habituation; and positive regulation of synaptic assembly at neuromuscular junction. Located in nucleus. Part of NuRD complex. Is expressed in organism. Used to study intellectual disability. Human ortholog(s) of this gene implicated in GAND syndrome. Orthologous to several human genes including GATAD2A (GATA zinc finger domain containing 2A). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See simj in Genome Data Viewer
    Location:
    67E6-67E6; 3-33 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (10664739..10690734)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (10657839..10683834)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Acireductone dioxygenase 1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene NADH dehydrogenase (ubiquinone) 13 kDa B subunit

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. ADI1, a methionine salvage pathway enzyme, is required for Drosophila fecundity. Chou HY, et al. J Biomed Sci, 2014 Jul 19. PMID 25037729, Free PMC Article
    2. GATAD2B loss-of-function mutations cause a recognisable syndrome with intellectual disability and are associated with learning deficits and synaptic undergrowth in Drosophila. Willemsen MH, et al. J Med Genet, 2013 Aug. PMID 23644463
    3. De Novo ZMYND8 variants result in an autosomal dominant neurodevelopmental disorder with cardiac malformations. Dias KR, et al. Genet Med, 2022 Sep. PMID 35916866
    4. Ush regulates hemocyte-specific gene expression, fatty acid metabolism and cell cycle progression and cooperates with dNuRD to orchestrate hematopoiesis. Lenz J, et al. PLoS Genet, 2021 Feb. PMID 33600407, Free PMC Article
    5. Habituation in high-throughput genetic model organisms as a tool to investigate the mechanisms of neurodevelopmental disorders. Kepler LD, et al. Neurobiol Learn Mem, 2020 May. PMID 32147587

    See all (63) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Neuronal knockdown of Drosophila GATAD2B orthologue, simj, resulted in impaired learning and altered synapse morphology
      Title: GATAD2B loss-of-function mutations cause a recognisable syndrome with intellectual disability and are associated with learning deficits and synaptic undergrowth in Drosophila.
    2. p66 is associated with the Mi-2/NURD complex and has developmental roles in Drosophila
      Title: Developmental roles of the Mi-2/NURD-associated protein p66 in Drosophila.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    mobile_element

    • Loc: 10668518-10668552 mobile_element_type = transposon:1731{}2231

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cardiac cell fate specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in habituation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of synaptic assembly at neuromuscular junction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of NuRD complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of NuRD complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    simjang
    Names
    CG32067-PA
    CG32067-PB
    CG32067-PC
    CG32067-PD
    CG32067-PE
    simj-PA
    simj-PB
    simj-PC
    simj-PD
    simj-PE

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      10664739..10690734
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001274756.1 → NP_001261685.1  simjang, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261685.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PF79
      Conserved Domains (1) summary
      pfam16563
      Location:185 → 222
      P66_CC; Coiled-coil and interaction region of P66A and P66B with MBD2

    2. NM_001274755.1 → NP_001261684.1  simjang, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261684.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PET3
      Conserved Domains (1) summary
      pfam16563
      Location:185 → 222
      P66_CC; Coiled-coil and interaction region of P66A and P66B with MBD2

    3. NM_168420.2 → NP_729624.1  simjang, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729624.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0E8G1
      Related
      FBpp0075992
      Conserved Domains (1) summary
      pfam16563
      Location:185 → 222
      P66_CC; Coiled-coil and interaction region of P66A and P66B with MBD2

    4. NM_140150.3 → NP_648407.1  simjang, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648407.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q960V1
      Related
      FBpp0075993
      Conserved Domains (1) summary
      pfam16563
      Location:185 → 222
      P66_CC; Coiled-coil and interaction region of P66A and P66B with MBD2

    5. NM_168421.2 → NP_729625.1  simjang, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729625.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0E8G1
      Related
      FBpp0075991
      Conserved Domains (1) summary
      pfam16563
      Location:185 → 222
      P66_CC; Coiled-coil and interaction region of P66A and P66B with MBD2
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PET3 M9PET3
    M9PF79 M9PF79
    Q0E8G1 Q0E8G1
    Q960V1 Q960V1

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