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    amon amontillado [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43215, updated on 9-Dec-2024

    Summary

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    Official Symbol
    amonprovided by FlyBase
    Official Full Name
    amontilladoprovided by FlyBase
    Primary source
    FLYBASE:FBgn0023179
    Locus tag
    Dmel_CG6438
    See related
    AllianceGenome:FB:FBgn0023179
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Amon; CG6438; Dmel\CG6438; DMH#5; dPC2; PC2; Ppp; PPP
    Summary
    Enables peptidase activity. Involved in several processes, including R8 cell fate specification; hatching behavior; and larval wandering behavior. Located in extracellular region. Is expressed in several structures, including adult head; ganglia; gut section; larval CNS neuron; and presumptive embryonic/larval system. Human ortholog(s) of this gene implicated in myocardial infarction and type 2 diabetes mellitus. Orthologous to human PCSK2 (proprotein convertase subtilisin/kexin type 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See amon in Genome Data Viewer
    Location:
    97C4-97C5; 3-91 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (26697697..26714159, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (22523419..22539881, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene beaten path VII Neighboring gene Tubby Neighboring gene TweedleQ Neighboring gene uncharacterized protein Neighboring gene Yip1-interacting factor 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Interaction of Drosophila melanogaster prohormone convertase 2 and 7B2. Insect cell-specific processing and secretion. Hwang JR, et al. J Biol Chem, 2000 Jun 9. PMID 10749852
    2. The proprotein convertase encoded by amontillado (amon) is required in Drosophila corpora cardiaca endocrine cells producing the glucose regulatory hormone AKH. Rhea JM, et al. PLoS Genet, 2010 May 27. PMID 20523747, Free PMC Article
    3. amontillado, the Drosophila homolog of the prohormone processing protease PC2, is required during embryogenesis and early larval development. Rayburn LY, et al. Genetics, 2003 Jan. PMID 12586710, Free PMC Article
    4. A role for amontillado, the Drosophila homolog of the neuropeptide precursor processing protease PC2, in triggering hatching behavior. Siekhaus DE, et al. J Neurosci, 1999 Aug 15. PMID 10436051, Free PMC Article
    5. The proprotein convertase amontillado (amon) is required during Drosophila pupal development. Rayburn LY, et al. Dev Biol, 2009 Sep 1. PMID 19559693, Free PMC Article

    See all (77) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. our findings provide the first direct evidence that AMON is a key enzyme in the production of neuropeptides in the fruitfly
      Title: Deficiency of prohormone convertase dPC2 (AMONTILLADO) results in impaired production of bioactive neuropeptide hormones in Drosophila.
    2. amon is required for pupal development and identify a subset of neuronal cell types in which amon function is sufficient to rescue developmental progression and growth defects shown by amon mutants.
      Title: The proprotein convertase amontillado (amon) is required during Drosophila pupal development.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables peptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables serine hydrolase activity HDA PubMed 
    enables serine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in R8 cell fate specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in carbohydrate homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in hatching behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in instar larval or pupal development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in larval wandering behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in peptide hormone processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in peptide hormone processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proteolysis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    amontillado
    Names
    CG6438-PA
    amon-PA
    prohormone processing protease
    NP_477318.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      26697697..26714159 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_057970.4 → NP_477318.1  amontillado [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477318.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9UAE7, Q9VBC7
      Related
      FBpp0084420
      Conserved Domains (5) summary
      cd04059
      Location:150 → 446
      Peptidases_S8_Protein_convertases_Kexins_Furin-like; Peptidase S8 family domain in Protein convertases
      pfam00082
      Location:187 → 459
      Peptidase_S8; Subtilase family
      pfam01483
      Location:534 → 621
      P_proprotein; Proprotein convertase P-domain
      pfam16470
      Location:43 → 122
      S8_pro-domain; Peptidase S8 pro-domain
      cl10459
      Location:409 → 485
      Peptidases_S8_S53; Peptidase domain in the S8 and S53 families
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VBC7.1 Q9VBC7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
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