Ilp5 Insulin-like peptide 5 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Ilp5provided by FlyBase
Official Full Name: Insulin-like peptide 5provided by FlyBase
Primary source: FLYBASE:FBgn0044048
Locus tag: Dmel_CG33273
See related: AllianceGenome:FB:FBgn0044048
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG33273; dilp; Dilp; DILP; Dilp 5; DILP 5; dilp-5; dILP-5; Dilp-5; DILP-5; Dilp1-5; dilp5; dIlp5; dILP5; Dilp5; DILP5; DILPs; dipl5; dlp; Dmel\CG33273; Ilp; Ilp-5; ilp5; ILP5; ILPs
Summary: Enables insulin receptor binding activity and receptor ligand activity. Involved in several processes, including female mating behavior; insulin receptor signaling pathway; and negative regulation of entry into reproductive diapause. Located in extracellular space. Is expressed in several structures, including Malpighian tubule Type I cell; brain; embryonic/larval corpus cardiacum; embryonic/larval midgut; and insulin secreting cell of pars intercerebralis. Used to study sleep disorder. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 67C9-67C9; 3-31 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (9823349..9823897, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (9816449..9816997, complement)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Using two long-lived IIS models, namely Drosophila lacking three insulin-like peptides (dilp2-3,5(-/-)) and mice lacking insulin receptor substrate 1 (Irs1(-/-)), and two independent translation assays, polysome profiling and radiolabeled amino acid incorporation, we show that reduced IIS lowers translation in these organisms
Title: Reduced insulin/insulin-like growth factor signaling decreases translation in Drosophila and mice.
The control of DILP5 signaling in the renal tubules by Drosophila tachykinin peptide (DTK) and its receptor DTKR during desiccative, nutritional and oxidative stress, was investigated.[Insulin]
Title: Insulin production and signaling in renal tubules of Drosophila is under control of tachykinin-related peptide and regulates stress resistance.
Results found that virgin females with knockout mutations of Ilp2, Ilp3 and Ilp5 show high mating success rate with higher locomotion.
Title: Knockout mutations of insulin-like peptide genes enhance sexual receptivity in Drosophila virgin females.
induction of dilp5 is critical for sustaining body growth under restricted food conditions
Title: Signaling from Glia and Cholinergic Neurons Controls Nutrient-Dependent Production of an Insulin-like Peptide for Drosophila Body Growth.
crystal structure of two variants of Drosophila melanogaster insulin-like peptide 5
Title: Structural and biological properties of the Drosophila insulin-like peptide 5 show evolutionary conservation.
show that the DILP-producing median neurosecretory cells are required to mediate nearly all of the response of lifespan and some of the response of fecundity to yeast levels
Title: DILP-producing median neurosecretory cells in the Drosophila brain mediate the response of lifespan to nutrition.

Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables hormone activity	IEA Inferred from Electronic Annotation more info
enables insulin receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables insulin receptor binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables receptor ligand activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in carbohydrate homeostasis	IDA Inferred from Direct Assay more info	PubMed
NOT involved_in circadian rhythm	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in female mating behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in insulin receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in insulin receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in locomotory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of entry into reproductive diapause	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sleep	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: Insulin-like peptide 5

Names: CG33273-PB; Ilp5-PB; Insulin-like peptide; drosophila insulin-like peptide 5; insulin like peptide 5; insulin-like peptide-5; insulin/insulin-like growth factor

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

9823349..9823897 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_206315.2 → NP_996037.2 Insulin-like peptide 5 [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/Swiss-Prot

Q6ILJ3, Q7KUD5

UniProtKB/TrEMBL

E7BBS4

Conserved Domains (1) summary

cd04366
Location:29 → 106

IlGF_insulin_bombyxin_like; IlGF_like family, insulin_bombyxin_like subgroup. Members include a number of peptides including insulin, insulin-like growth factors I and II, insect prothoracicotropic hormone (bombyxin), locust insulin-related peptide (LIRP), molluscan insulin-related ...