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    Phm Peptidylglycine-alpha-hydroxylating monooxygenase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37823, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Phmprovided by FlyBase
    Official Full Name
    Peptidylglycine-alpha-hydroxylating monooxygenaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0283509
    Locus tag
    Dmel_CG3832
    See related
    AllianceGenome:FB:FBgn0283509
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG3832; Dmel\CG3832; dPHM; lance-b; ll; phm; PHM
    Summary
    Enables peptidylglycine monooxygenase activity. Involved in memory and regulation of imaginal disc-derived wing size. Located in extracellular space. Is expressed in several structures, including brain; gland; mushroom body; neurosecretory neurons; and peritracheal cell. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Phm in Genome Data Viewer
    Location:
    60A16-60A16; 2-105 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (23985175..23988455, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (19872698..19875978, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene morula Neighboring gene Protein phosphatase 1 regulatory subunit 15 Neighboring gene Sox box protein 14 Neighboring gene uncharacterized protein Neighboring gene PAS kinase Neighboring gene uncharacterized protein Neighboring gene mir-1009 stem loop

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization of an SRY-like gene, DSox14, from Drosophila. Sparkes AC, et al. Gene, 2001 Jul 11. PMID 11470517
    2. Distinct Regulation of Transmitter Release at the Drosophila NMJ by Different Isoforms of nemy. Knight D, et al. PLoS One, 2015. PMID 26237434, Free PMC Article
    3. Regulation of secretory protein expression in mature cells by DIMM, a basic helix-loop-helix neuroendocrine differentiation factor. Hewes RS, et al. J Neurosci, 2006 Jul 26. PMID 16870731, Free PMC Article
    4. Light-arousal and circadian photoreception circuits intersect at the large PDF cells of the Drosophila brain. Shang Y, et al. Proc Natl Acad Sci U S A, 2008 Dec 16. PMID 19060186, Free PMC Article
    5. In vivo characterization of the maturation steps of a pigment dispersing factor neuropeptide precursor in the Drosophila circadian pacemaker neurons. Lee GG, et al. Genetics, 2023 Aug 31. PMID 37364299, Free PMC Article

    See all (79) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. DIMM is a master regulator of a peptidergic cell fate in Drosophila and provides a detailed transcriptional mechanism of DIMM action on a defined target gene
      Title: The Drosophila basic helix-loop-helix protein DIMMED directly activates PHM, a gene encoding a neuropeptide-amidating enzyme.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables copper ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen IEA
    Inferred from Electronic Annotation
    more info
    		  
    NOT enables peptidylamidoglycolate lyase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables peptidylglycine monooxygenase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in memory IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in peptide metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of imaginal disc-derived wing size IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to fungus HEP PubMed 
    involved_in sexual reproduction HEP PubMed 
    Component Evidence Code Pubs
    is_active_in extracellular region IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space HDA PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Peptidylglycine-alpha-hydroxylating monooxygenase
    Names
    CG3832-PA
    CG3832-PB
    Phm-PA
    Phm-PB
    lanceolate
    lanceolote
    peptidyl gycine alpha hydroxylating monooxygenase
    peptidylglycine alpha-hydroxylating monooxygenase
    peptidylglycine-alpha-hydroxylating monooxygenase
    NP_477225.1
    NP_726394.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      23985175..23988455 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_057877.4 → NP_477225.1  Peptidylglycine-alpha-hydroxylating monooxygenase, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477225.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O01402, O01403, O01404, O01405, O01406, O01407, O01408, Q7JNH8, Q7JNH9, Q7JNI0, Q7JNI1, Q7JNI2, Q7JNI3, Q7JNI4
      UniProtKB/TrEMBL
      E2QCL8
      Related
      FBpp0072112
      Conserved Domains (2) summary
      pfam01082
      Location:51 → 179
      Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain
      pfam03712
      Location:201 → 350
      Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain

    2. NM_166644.2 → NP_726394.1  Peptidylglycine-alpha-hydroxylating monooxygenase, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726394.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O01402, O01403, O01404, O01405, O01406, O01407, O01408, Q7JNH8, Q7JNH9, Q7JNI0, Q7JNI1, Q7JNI2, Q7JNI3, Q7JNI4
      UniProtKB/TrEMBL
      E2QCL8
      Related
      FBpp0072111
      Conserved Domains (2) summary
      pfam01082
      Location:51 → 179
      Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain
      pfam03712
      Location:201 → 350
      Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    E2QCL8 E2QCL8
    O01404.2 O01404

    Gene LinkOut

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