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    Htr1a 5-hydroxytryptamine (serotonin) receptor 1A [ Mus musculus (house mouse) ]

    Gene ID: 15550, updated on 13-Jan-2025

    Summary

    Official Symbol
    Htr1aprovided by MGI
    Official Full Name
    5-hydroxytryptamine (serotonin) receptor 1Aprovided by MGI
    Primary source
    MGI:MGI:96273
    See related
    Ensembl:ENSMUSG00000021721 AllianceGenome:MGI:96273
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gpcr18
    Summary
    Enables G protein-coupled serotonin receptor activity. Involved in several processes, including behavioral fear response; regulation of serotonin secretion; and serotonin receptor signaling pathway. Acts upstream of or within gamma-aminobutyric acid signaling pathway. Predicted to be located in axon hillock. Predicted to be active in GABA-ergic synapse; dendrite; and presynaptic membrane. Is expressed in several structures, including central nervous system; exocrine gland; eye; genitourinary system; and intestine. Used to study anxiety disorder. Human ortholog(s) of this gene implicated in alcohol dependence; anxiety disorder (multiple); depressive disorder; substance abuse; and withdrawal disorder. Orthologous to human HTR1A (5-hydroxytryptamine receptor 1A). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
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    Genomic context

    See Htr1a in Genome Data Viewer
    Location:
    13 D1; 13 56.92 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (105580040..105584630)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (105443693..105448133)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 41049 Neighboring gene predicted gene, 31130 Neighboring gene STARR-seq mESC enhancer starr_35552 Neighboring gene predicted gene, 41050 Neighboring gene STARR-seq mESC enhancer starr_35553 Neighboring gene VISTA enhancer mm5 Neighboring gene predicted gene, 57602

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (11)  1 citation

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled serotonin receptor activity  
    enables G protein-coupled serotonin receptor activity PubMed 
    enables G protein-coupled serotonin receptor activity PubMed 
    enables G protein-coupled serotonin receptor activity  
    enables G-protein alpha-subunit binding  
    enables Gi/o-coupled serotonin receptor activity  
    enables neurotransmitter receptor activity  
    enables receptor-receptor interaction  
    enables receptor-receptor interaction  
    enables serotonin binding  
    enables serotonin binding  
    enables serotonin receptor activity  
    enables signaling receptor binding  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway  
    involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger  
    involved_in NMDA glutamate receptor clustering  
    involved_in adenylate cyclase-inhibiting serotonin receptor signaling pathway  
    involved_in adenylate cyclase-inhibiting serotonin receptor signaling pathway  
    involved_in adenylate cyclase-inhibiting serotonin receptor signaling pathway  
    involved_in behavioral fear response PubMed 
    involved_in chemical synaptic transmission  
    involved_in exploration behavior PubMed 
    acts_upstream_of_or_within gamma-aminobutyric acid signaling pathway PubMed 
    involved_in negative regulation of gamma-aminobutyric acid secretion  
    involved_in positive regulation of microtubule depolymerization  
    involved_in presynaptic modulation of chemical synaptic transmission  
    involved_in regulation of behavior  
    involved_in regulation of dopamine metabolic process PubMed 
    involved_in regulation of feeding behavior  
    involved_in regulation of hormone secretion  
    involved_in regulation of serotonin secretion PubMed 
    involved_in regulation of vasoconstriction  
    involved_in serotonin metabolic process PubMed 
    involved_in serotonin receptor signaling pathway PubMed 
    involved_in serotonin receptor signaling pathway  
    Component Evidence Code Pubs
    is_active_in GABA-ergic synapse  
    located_in axon hillock  
    is_active_in dendrite  
    located_in dendrite  
    located_in neuronal cell body  
    is_active_in plasma membrane  
    located_in plasma membrane  
    located_in plasma membrane  
    is_active_in presynaptic membrane  

    General protein information

    Preferred Names
    5-hydroxytryptamine receptor 1A
    Names
    5-HT-1A
    5-HT1A receptor
    G-protein coupled receptor 18
    serotonin receptor 1A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008308.5NP_032334.2  5-hydroxytryptamine receptor 1A

      See identical proteins and their annotated locations for NP_032334.2

      Status: VALIDATED

      Source sequence(s)
      AC114573
      Consensus CDS
      CCDS26756.1
      UniProtKB/Swiss-Prot
      Q60956, Q61617, Q64264, Q8BGS4
      UniProtKB/TrEMBL
      Q8BZP1
      Related
      ENSMUSP00000022235.5, ENSMUST00000022235.6
      Conserved Domains (2) summary
      pfam00001
      Location:53400
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:48169
      7tm_4; Olfactory receptor

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      105580040..105584630
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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