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    ZSCAN29 zinc finger and SCAN domain containing 29 [ Homo sapiens (human) ]

    Gene ID: 146050, updated on 10-Dec-2024

    Summary

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    Official Symbol
    ZSCAN29provided by HGNC
    Official Full Name
    zinc finger and SCAN domain containing 29provided by HGNC
    Primary source
    HGNC:HGNC:26673
    See related
    Ensembl:ENSG00000140265 MIM:620932; AllianceGenome:HGNC:26673
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ZNF690; Zfp690
    Summary
    Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in testis (RPKM 6.9), lymph node (RPKM 3.9) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ZSCAN29 in Genome Data Viewer
    Location:
    15q15.3
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (43358175..43371043, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (41165501..41178380, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (43650373..43663241, complement)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr15:43589862-43590498 Neighboring gene transglutaminase 7 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:43622679-43623629 Neighboring gene leucine carboxyl methyltransferase 2 Neighboring gene N6-Methyl-AMP deaminase Neighboring gene ReSE screen-validated silencer GRCh37_chr15:43647073-43647266 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9313 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6385 Neighboring gene tubulin gamma complex component 4 Neighboring gene RNA, 7SL, cytoplasmic 487, pseudogene Neighboring gene tumor protein p53 binding protein 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:43734212-43734815 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:43769402-43769643 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr15:43784380-43785088 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr15:43785089-43785795 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:43787292-43787792 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9314

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Congenital dyserythropoietic anemia type I is caused by mutations in codanin-1. Dgany O, et al. Am J Hum Genet, 2002 Dec. PMID 12434312, Free PMC Article
    2. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Yin Y, et al. Science, 2017 May 5. PMID 28473536, Free PMC Article
    3. The Tumor Suppressor CIC Directly Regulates MAPK Pathway Genes via Histone Deacetylation. Weissmann S, et al. Cancer Res, 2018 Aug 1. PMID 29844126, Free PMC Article
    4. MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons. Liu Y, et al. Neuron, 2024 Jun 19. PMID 38697112
    5. H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids. Nakamura K, et al. Nat Cell Biol, 2019 Mar. PMID 30804502, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ35867, MGC129894, MGC129895

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sequence-specific double-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger and SCAN domain-containing protein 29
    Names
    KOX31-like zinc finger protein
    zinc finger protein 690

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001372080.1 → NP_001359009.1  zinc finger and SCAN domain-containing protein 29

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AC018924
      Consensus CDS
      CCDS10095.2
      UniProtKB/Swiss-Prot
      B3KVB9, Q32M75, Q32M76, Q8IWY8, Q8NA40
      Related
      ENSP00000507363.1, ENST00000684362.1
      Conserved Domains (4) summary
      smart00431
      Location:14 → 124
      SCAN; leucine rich region
      COG5048
      Location:630 → 838
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:680 → 700
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13837
      Location:408 → 493
      Myb_DNA-bind_4; Myb/SANT-like DNA-binding domain

    2. NM_152455.4 → NP_689668.3  zinc finger and SCAN domain-containing protein 29

      See identical proteins and their annotated locations for NP_689668.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AC018924, AF525399, BC017179, BC043612, DB183454, DB365228
      Consensus CDS
      CCDS10095.2
      UniProtKB/Swiss-Prot
      B3KVB9, Q32M75, Q32M76, Q8IWY8, Q8NA40
      Related
      ENSP00000380174.2, ENST00000396976.6
      Conserved Domains (4) summary
      smart00431
      Location:14 → 124
      SCAN; leucine rich region
      COG5048
      Location:630 → 838
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:680 → 700
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13837
      Location:408 → 493
      Myb_DNA-bind_4; Myb/SANT-like DNA-binding domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

      Range
      43358175..43371043 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047432187.1 → XP_047288143.1  zinc finger and SCAN domain-containing protein 29 isoform X1

      UniProtKB/Swiss-Prot
      B3KVB9, Q32M75, Q32M76, Q8IWY8, Q8NA40

    2. XM_047432188.1 → XP_047288144.1  zinc finger and SCAN domain-containing protein 29 isoform X2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060939.1 Alternate T2T-CHM13v2.0

      Range
      41165501..41178380 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054377352.1 → XP_054233327.1  zinc finger and SCAN domain-containing protein 29 isoform X1

      UniProtKB/Swiss-Prot
      B3KVB9, Q32M75, Q32M76, Q8IWY8, Q8NA40

    2. XM_054377353.1 → XP_054233328.1  zinc finger and SCAN domain-containing protein 29 isoform X2

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IWY8.2 GenPept UniProtKB/Swiss-Prot:Q8IWY8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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