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    pde-4 Phosphodiesterase;putative 3',5'-cyclic-AMP phosphodiesterase pde-4 [ Caenorhabditis elegans ]

    Gene ID: 174235, updated on 9-Dec-2024

    Summary

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    Official Symbol
    pde-4
    Official Full Name
    Phosphodiesterase;putative 3',5'-cyclic-AMP phosphodiesterase pde-4
    Primary source
    WormBase:WBGene00020114
    Locus tag
    CELE_R153.1
    See related
    AllianceGenome:WB:WBGene00020114
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable 3',5'-cyclic-AMP phosphodiesterase activity and 3',5'-cyclic-GMP phosphodiesterase activity. Involved in several processes, including adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway; and sleep. Located in synapse. Is expressed in neurons. Human ortholog(s) of this gene implicated in acrodysostosis and alcohol dependence. Orthologous to several human genes including PDE4B (phosphodiesterase 4B). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See pde-4 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    16
    Sequence:
    Chromosome: II; NC_003280.10 (7627250..7651246, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ALS/FTD Associated gene homolog

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Lifespan extension in Caenorhabditis elegans by oxyresveratrol supplementation in hyper-branched cyclodextrin-based nanosponges. Matencio A, et al. Int J Pharm, 2020 Nov 15. PMID 32916214
    2. EGL-4 promotes turning behavior of C. elegans males during mating. Rahmani S, et al. MicroPubl Biol, 2021. PMID 34423280, Free PMC Article
    3. Convergent Transcriptional Programs Regulate cAMP Levels in C. elegans GABAergic Motor Neurons. Yu B, et al. Dev Cell, 2017 Oct 23. PMID 29033363
    4. Lethargus is a Caenorhabditis elegans sleep-like state. Raizen DM, et al. Nature, 2008 Jan 31. PMID 18185515
    5. The Receptor-Bound Guanylyl Cyclase DAF-11 Is the Mediator of Hydrogen Peroxide-Induced cGMP Increase in Caenorhabditis elegans [corrected]. Beckert U, et al. PLoS One, 2013. PMID 24015261, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Loss of function and neural overexpression of PDE-4 have profound and opposite effects on locomotion rate, but drug-response assays suggest that loss of PDE-4 function does not affect steady-state acetylcholine release or reception.
      Title: The Dunce cAMP phosphodiesterase PDE-4 negatively regulates G alpha(s)-dependent and G alpha(s)-independent cAMP pools in the Caenorhabditis elegans synaptic signaling network.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables 3',5'-cyclic-AMP phosphodiesterase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 3',5'-cyclic-AMP phosphodiesterase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 3',5'-cyclic-AMP phosphodiesterase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables 3',5'-cyclic-GMP phosphodiesterase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 3',5'-cyclic-nucleotide phosphodiesterase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoric diester hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cAMP catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in cAMP-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell communication IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of locomotion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signaling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sleep IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Phosphodiesterase;putative 3',5'-cyclic-AMP phosphodiesterase pde-4
    NP_001040798.1
    • Confirmed by transcript evidence
    NP_001293472.1
    • Confirmed by transcript evidence
    NP_001379885.1
    • Confirmed by transcript evidence
    NP_001379886.1
    • Confirmed by transcript evidence
    NP_495600.1
    • Confirmed by transcript evidence
    NP_495601.1
    • Confirmed by transcript evidence
    NP_871945.1
    • Confirmed by transcript evidence
    NP_871947.1
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      7627250..7651246 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001393119.1 → NP_001379885.1  putative 3',5'-cyclic-AMP phosphodiesterase pde-4 [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (2) summary
      pfam00233
      Location:344 → 585
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam18100
      Location:95 → 211
      PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)

    2. NM_182145.6 → NP_871945.1  putative 3',5'-cyclic-AMP phosphodiesterase pde-4 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_871945.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q22000, Q86NE7, Q86NE8, Q86NE9, Q8IFZ3, Q95ZQ6
      Conserved Domains (1) summary
      pfam00233
      Location:406 → 647
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

    3. NM_063200.5 → NP_495601.1  putative 3',5'-cyclic-AMP phosphodiesterase pde-4 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_495601.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q22000
      Conserved Domains (1) summary
      pfam00233
      Location:281 → 522
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

    4. NM_001047333.6 → NP_001040798.1  Phosphodiesterase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001040798.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q2V4U0
      Conserved Domains (1) summary
      pfam00233
      Location:405 → 646
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

    5. NM_001306543.3 → NP_001293472.1  Phosphodiesterase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293472.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      S6FCW6
      Conserved Domains (1) summary
      pfam00233
      Location:356 → 597
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

    6. NM_063199.7 → NP_495600.1  putative 3',5'-cyclic-AMP phosphodiesterase pde-4 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_495600.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q22000
      Conserved Domains (1) summary
      pfam00233
      Location:358 → 599
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

    7. NM_001393120.1 → NP_001379886.1  putative 3',5'-cyclic-AMP phosphodiesterase pde-4 [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (2) summary
      pfam00233
      Location:331 → 572
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam18100
      Location:82 → 198
      PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)

    8. NM_182147.5 → NP_871947.1  putative 3',5'-cyclic-AMP phosphodiesterase pde-4 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_871947.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q22000
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q22000.2

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