trp-1 Transient receptor ion channel domain-containing protein;Transient-receptor-potential-like protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: trp-1
Official Full Name: Transient receptor ion channel domain-containing protein;Transient-receptor-potential-like protein
Primary source: WormBase:WBGene00006614
Locus tag: CELE_ZC21.2
See related: AllianceGenome:WB:WBGene00006614
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable inositol 1,4,5 trisphosphate binding activity and store-operated calcium channel activity. Predicted to be involved in calcium ion transmembrane transport; regulation of cytosolic calcium ion concentration; and single fertilization. Predicted to be located in membrane. Predicted to be part of cation channel complex. Predicted to be active in plasma membrane. Is expressed in neurons and non-striated muscle. Used to study nicotine dependence. Human ortholog(s) of this gene implicated in cerebellar ataxia type 41; chronic fatigue syndrome; focal segmental glomerulosclerosis (multiple); lung cancer; and nephrotic syndrome type 2. Orthologous to human TRPC3 (transient receptor potential cation channel subfamily C member 3); TRPC6 (transient receptor potential cation channel subfamily C member 6); and TRPC7 (transient receptor potential cation channel subfamily C member 7). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See trp-1 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 17

Sequence:: Chromosome: III; NC_003281.10 (8535131..8542748)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The authors identify two transient receptor potential cation (TRPC) channels, trp-1 and trp-2, as necessary and sufficient for proprioceptive responses in C. elegans head steering locomotion.
Title: A sensory-motor neuron type mediates proprioceptive coordination of steering in C. elegans via two TRPC channels.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

ZC21.2 (e-PCR)
- UniSTS:310343

ZC21.1 (e-PCR)
- UniSTS:319817

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables calcium channel activity	IEA Inferred from Electronic Annotation more info
enables inositol 1,4,5 trisphosphate binding	IBA Inferred from Biological aspect of Ancestor more info
enables monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info
enables store-operated calcium channel activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in calcium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in calcium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of cytosolic calcium ion concentration	IBA Inferred from Biological aspect of Ancestor more info
involved_in single fertilization	IBA Inferred from Biological aspect of Ancestor more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of cation channel complex	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Transient receptor ion channel domain-containing protein;Transient-receptor-potential-like protein

NP_001040889.1

Confirmed by transcript evidence

NP_001367402.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

8535131..8542748

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001047424.3 → NP_001040889.1 Transient-receptor-potential-like protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001040889.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P34585, P34586, Q8IG03

Conserved Domains (4) summary

cd00204
Location:56 → 184

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

TIGR00870
Location:34 → 805

trp; transient-receptor-potential calcium channel protein

pfam08344
Location:198 → 257

TRP_2; Transient receptor ion channel II

sd00045
Location:85 → 115

ANK; ANK repeat [structural motif]
NM_001379835.1 → NP_001367402.1 Transient receptor ion channel domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

Q27GV1

Conserved Domains (2) summary

TIGR00870
Location:38 → 809

trp; transient-receptor-potential calcium channel protein

sd00045
Location:89 → 119

ANK; ANK repeat [structural motif]