U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    fat-4 Delta(5) fatty acid desaturase fat-4 [ Caenorhabditis elegans ]

    Gene ID: 177819, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    fat-4
    Official Full Name
    Delta(5) fatty acid desaturase fat-4
    Primary source
    WormBase:WBGene00001396
    Locus tag
    CELE_T13F2.1
    See related
    AllianceGenome:WB:WBGene00001396
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables stearoyl-CoA 9-desaturase activity. Involved in unsaturated fatty acid biosynthetic process. Predicted to be located in membrane. Is expressed in intestine; nerve ring; and touch receptor neurons. Used to study alcohol use disorder. Orthologous to several human genes including FADS1 (fatty acid desaturase 1). [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See fat-4 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    8
    Sequence:
    Chromosome: IV; NC_003282.8 (9799429..9802226)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene FTH domain-containing protein Neighboring gene BRCT domain-containing protein Neighboring gene Putative RNA polymerase II transcriptional coactivator Neighboring gene Delta(6)-fatty-acid desaturase fat-3;Fatty acid desaturase domain-containing protein Neighboring gene RGS domain-containing protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Isolation and characterization of a Delta 5-fatty acid desaturase from Caenorhabditis elegans. Watts JL, et al. Arch Biochem Biophys, 1999 Feb 1. PMID 9917342
    2. Identification and characterization of an animal delta(12) fatty acid desaturase gene by heterologous expression in Saccharomyces cerevisiae. Peyou-Ndi MM, et al. Arch Biochem Biophys, 2000 Apr 15. PMID 10775428
    3. Specific polyunsaturated fatty acids modulate lipid delivery and oocyte development in C. elegans revealed by molecular-selective label-free imaging. Chen WW, et al. Sci Rep, 2016 Aug 18. PMID 27535493, Free PMC Article
    4. Impact of Molecular Weight Variations in Dendrobium officinale Polysaccharides on Antioxidant Activity and Anti-Obesity in Caenorhabditis elegans. Pang X, et al. Foods, 2024 Mar 28. PMID 38611346, Free PMC Article
    5. The cytochrome b5 reductase HPO-19 is required for biosynthesis of polyunsaturated fatty acids in Caenorhabditis elegans. Zhang Y, et al. Biochim Biophys Acta, 2016 Apr. PMID 26806391

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables acyl-CoA delta5-desaturase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables stearoyl-CoA 9-desaturase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in fatty acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lipid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in unsaturated fatty acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in unsaturated fatty acid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    Delta(5) fatty acid desaturase fat-4
    NP_001255423.1
    • Partially confirmed by transcript evidence
    NP_001255424.1
    • Partially confirmed by transcript evidence
    NP_001255425.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      9799429..9802226
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001268494.2 → NP_001255423.1  Delta(5) fatty acid desaturase fat-4 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255423.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D5MCT8, E9P887, G5EG11
      Conserved Domains (2) summary
      cd03506
      Location:153 → 414
      Delta6-FADS-like; The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases ...
      pfam00487
      Location:152 → 417
      FA_desaturase; Fatty acid desaturase

    2. NM_001268495.3 → NP_001255424.1  Delta(5) fatty acid desaturase fat-4 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255424.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G5EG11
      Conserved Domains (2) summary
      cd03506
      Location:62 → 323
      Delta6-FADS-like; The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases ...
      pfam00487
      Location:61 → 326
      FA_desaturase; Fatty acid desaturase

    3. NM_001268496.3 → NP_001255425.1  Delta(5) fatty acid desaturase fat-4 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255425.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G5EG11
      Conserved Domains (1) summary
      cl00615
      Location:1 → 22
      Membrane-FADS-like; The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    G5EG11.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous