unc-3 Transcription factor unc-3 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: unc-3
Official Full Name: Transcription factor unc-3
Primary source: WormBase:WBGene00006743
Locus tag: CELE_Y16B4A.1
See related: AllianceGenome:WB:WBGene00006743
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; histone acetyltransferase binding activity; and identical protein binding activity. Involved in several processes, including dauer larval development; neuron differentiation; and positive regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in ABalappaap; ABalappaapp; and neurons. Human ortholog(s) of this gene implicated in hypotonia, ataxia, and delayed development syndrome. Orthologous to several human genes including EBF4 (EBF family member 4); EBF1 (EBF transcription factor 1); and EBF2 (EBF transcription factor 2). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See unc-3 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 12

Sequence:: Chromosome: X; NC_003284.9 (14773538..14783568)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A terminal selector prevents a Hox transcriptional switch to safeguard motor neuron identity throughout life.
Title: A terminal selector prevents a Hox transcriptional switch to safeguard motor neuron identity throughout life.
Unc-3 is required for synaptogenesis.Synaptic input and output properties are temporally coordinated by Unc-3.
Title: Transcriptional coordination of synaptogenesis and neurotransmitter signaling.
in addition to playing a role in neuronal terminal differentiation, UNC-3 is a cell lineage-specific regulator of apoptosis.
Title: The C. elegans COE transcription factor UNC-3 activates lineage-specific apoptosis and affects neurite growth in the RID lineage.
UNC-3 is a terminal selector for cholinergic motor neuron differentiation whose function is conserved across phylogeny.
Title: Coordinated regulation of cholinergic motor neuron traits through a conserved terminal selector gene.
unc-3 represses a VC-like motor neuron program in the VA and VB motor neurons, which in wild-type animals control backwards and forwards locomotion, respectively.
Title: unc-3-dependent repression of specific motor neuron fates in Caenorhabditis elegans.
UNC-3 is a critical component of the transcription factor code that integrates cell-intrinsic developmental programs with external signals to specify sensory neuronal identity
Title: The UNC-3 Olf/EBF protein represses alternate neuronal programs to specify chemosensory neuron identity.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F42D1.1 (e-PCR)
- UniSTS:314306

Y16B4A.1 (e-PCR)
- UniSTS:319736

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables histone acetyltransferase binding	IPI Inferred from Physical Interaction more info	PubMed
enables identical protein binding	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell fate specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dauer larval development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in neuron fate specification	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of neuron projection development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Transcription factor unc-3

NP_510453.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

14773538..14783568

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_078052.5 → NP_510453.1 Transcription factor unc-3 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_510453.1

Status: REVIEWED

UniProtKB/Swiss-Prot

K8FE05, O61576, Q93705

Conserved Domains (3) summary

cd11606
Location:45 → 249

COE_DBD; Colier/Olf/Early B-cell factor (EBF) DNA Binding Domain

cd01175
Location:269 → 357

IPT_COE; IPT domain of the COE family (Col/Olf-1/EBF) of non-basic, helix-loop-helix (HLH)-containing transcription factors. COE family proteins are all transcription factors and play an important role in variety of developmental processes. Mouse EBF is involved ...

pfam16423
Location:358 → 401

COE1_HLH; Transcription factor COE1 helix-loop-helix domain