R12E2.11 Orotate phosphoribosyltransferase [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: R12E2.11
Official Full Name: Orotate phosphoribosyltransferase
Primary source: WormBase:WBGene00020036
Locus tag: CELE_R12E2.11
See related: AllianceGenome:WB:WBGene00020036
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables orotate phosphoribosyltransferase activity. Involved in UMP biosynthetic process. Is expressed in body wall musculature; intestine; spermatheca; and vulval muscle. Human ortholog(s) of this gene implicated in orotic aciduria and purine-pyrimidine metabolic disorder. Orthologous to human UMPS (uridine monophosphate synthetase). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See R12E2.11 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 3

Sequence:: Chromosome: I; NC_003279.8 (4172438..4173624, complement)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

R12E2.12 (e-PCR)
- UniSTS:306710

R12E2.11 (e-PCR)
- UniSTS:316998

STS1-138 (e-PCR)
- UniSTS:241624

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables glycosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables orotate phosphoribosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables orotate phosphoribosyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables orotate phosphoribosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables orotidine-5'-phosphate decarboxylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables uracil phosphoribosyltransferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in 'de novo' UMP biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in UMP biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in UMP biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in UMP salvage	IEA Inferred from Electronic Annotation more info
involved_in pyrimidine nucleobase biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in pyrimidine nucleotide biosynthetic process	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Orotate phosphoribosyltransferase

NP_491317.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

4172438..4173624 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_058916.6 → NP_491317.1 Orotate phosphoribosyltransferase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_491317.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O61790

Conserved Domains (1) summary

COG0461
Location:32 → 221

PyrE; Orotate phosphoribosyltransferase [Nucleotide transport and metabolism]