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    cfim-2 Cleavage and polyadenylation specificity factor subunit 6;RRM domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 177710, updated on 9-Dec-2024

    Summary

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    Official Symbol
    cfim-2
    Official Full Name
    Cleavage and polyadenylation specificity factor subunit 6;RRM domain-containing protein
    Primary source
    WormBase:WBGene00008362
    Locus tag
    CELE_D1046.1
    See related
    AllianceGenome:WB:WBGene00008362
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable mRNA binding activity. Predicted to be involved in mRNA alternative polyadenylation. Predicted to be located in nucleus. Predicted to be part of mRNA cleavage and polyadenylation specificity factor complex. Is expressed in several structures, including anal depressor muscle; coelomocyte; head mesodermal cell; rectum; and reproductive system. Orthologous to several human genes including CPSF7 (cleavage and polyadenylation specific factor 7). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See cfim-2 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    13
    Sequence:
    Chromosome: IV; NC_003282.8 (8926328..8930346)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene C2H2-type domain-containing protein Neighboring gene ncRNA Neighboring gene tRNA Neighboring gene ncRNA Neighboring gene Mitochondrial carrier protein PET8 Neighboring gene Uncharacterized protein Neighboring gene MFS domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The C. elegans 3' UTRome v2 resource for studying mRNA cleavage and polyadenylation, 3'-UTR biology, and miRNA targeting. Steber HS, et al. Genome Res, 2019 Dec. PMID 31744903, Free PMC Article
    2. An evolutionarily conserved role for SRm160 in 3'-end processing that functions independently of exon junction complex formation. McCracken S, et al. J Biol Chem, 2003 Nov 7. PMID 12944400
    3. Genes involved in pre-mRNA 3'-end formation and transcription termination revealed by a lin-15 operon Muv suppressor screen. Cui M, et al. Proc Natl Acad Sci U S A, 2008 Oct 28. PMID 18946043, Free PMC Article
    4. PHA-4/FoxA cooperates with TAM-1/TRIM to regulate cell fate restriction in the C. elegans foregut. Kiefer JC, et al. Dev Biol, 2007 Mar 15. PMID 17250823, Free PMC Article
    5. Integrating interactome, phenome, and transcriptome mapping data for the C. elegans germline. Walhout AJ, et al. Curr Biol, 2002 Nov 19. PMID 12445390

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in mRNA alternative polyadenylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of mRNA cleavage and polyadenylation specificity factor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Cleavage and polyadenylation specificity factor subunit 6;RRM domain-containing protein
    NP_001367218.1
    • Confirmed by transcript evidence
    NP_001368144.1
    • Confirmed by transcript evidence
    NP_001369896.1
    • Confirmed by transcript evidence
    NP_001370253.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      8926328..8930346
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001380391.2 → NP_001367218.1  RRM domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      C6KRJ2
      Conserved Domains (1) summary
      cd12643
      Location:85 → 163
      RRM_CFIm68; RNA recognition motif (RRM) found in pre-mRNA cleavage factor Im 68 kDa subunit (CFIm68 or CPSF6) and similar proteins

    2. NM_001383157.2 → NP_001369896.1  RRM domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q18937
      Conserved Domains (2) summary
      TIGR01628
      Location:251 → 362
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      cd12643
      Location:85 → 163
      RRM_CFIm68; RNA recognition motif (RRM) found in pre-mRNA cleavage factor Im 68 kDa subunit (CFIm68 or CPSF6) and similar proteins

    3. NM_001383156.2 → NP_001370253.1  RRM domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      C1P629
      Conserved Domains (2) summary
      TIGR01628
      Location:253 → 364
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      cd12643
      Location:87 → 165
      RRM_CFIm68; RNA recognition motif (RRM) found in pre-mRNA cleavage factor Im 68 kDa subunit (CFIm68 or CPSF6) and similar proteins

    4. NM_001380392.1 → NP_001368144.1  Cleavage and polyadenylation specificity factor subunit 6 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      I7KSC2
      Conserved Domains (1) summary
      TIGR01628
      Location:55 → 166
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    Nucleotide Protein
    Heading Accession and Version

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