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    npr-18 Neuropeptide receptor 18 [ Caenorhabditis elegans ]

    Gene ID: 183408, updated on 9-Dec-2024

    Summary

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    Official Symbol
    npr-18
    Official Full Name
    Neuropeptide receptor 18
    Primary source
    WormBase:WBGene00008065
    Locus tag
    CELE_C43C3.2
    See related
    AllianceGenome:WB:WBGene00008065
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable G protein-coupled receptor activity and peptide binding activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in neuron projection and plasma membrane. Is expressed in neurons. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See npr-18 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    12
    Sequence:
    Chromosome: X; NC_003284.9 (9690745..9696723)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Penicillin-binding protein Neighboring gene Intermediate filament protein ifp-1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Protein dyf-7 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Dissecting the signaling mechanisms underlying recognition and preference of food odors. Harris G, et al. J Neurosci, 2014 Jul 9. PMID 25009271, Free PMC Article
    2. Innate immunity in Caenorhabditis elegans is regulated by neurons expressing NPR-1/GPCR. Styer KL, et al. Science, 2008 Oct 17. PMID 18801967, Free PMC Article
    3. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptide binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Neuropeptide receptor 18
    NP_001257083.1
    • Partially confirmed by transcript evidence
    NP_001257085.1
    • Partially confirmed by transcript evidence
    NP_001257088.1
    • Partially confirmed by transcript evidence
    NP_001368133.1
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      9690745..9696723
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001270154.3 → NP_001257083.1  Neuropeptide receptor 18 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001257083.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      I2HAC8
      Conserved Domains (1) summary
      cd00637
      Location:50 → 355
      7tm_classA_rhodopsin-like; rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily

    2. NM_001270156.3 → NP_001257085.1  Neuropeptide receptor 18 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001257085.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      I2HAC6, I2HAC8, I2HAC9, I2HAD0, Q09502
      Conserved Domains (1) summary
      cd00637
      Location:63 → 368
      7tm_classA_rhodopsin-like; rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily

    3. NM_001381071.2 → NP_001368133.1  Neuropeptide receptor 18 [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (1) summary
      cd00637
      Location:34 → 339
      7tm_classA_rhodopsin-like; rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily

    4. NM_001270159.3 → NP_001257088.1  Neuropeptide receptor 18 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001257088.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      I2HAC6
      Conserved Domains (1) summary
      cd00637
      Location:63 → 368
      7tm_classA_rhodopsin-like; rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily
    Nucleotide Protein
    Heading Accession and Version

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