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    ech-4 ACB domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 174665, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ech-4
    Official Full Name
    ACB domain-containing protein
    Primary source
    WormBase:WBGene00001153
    Locus tag
    CELE_R06F6.9
    See related
    AllianceGenome:WB:WBGene00001153
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable fatty-acyl-CoA binding activity. Involved in fatty acid beta-oxidation and lipid storage. Is expressed in hypodermis and intestine. Orthologous to human ECI2 (enoyl-CoA delta isomerase 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ech-4 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    3
    Sequence:
    Chromosome: II; NC_003280.10 (10821031..10822391)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene MS Related Protein Neighboring gene Guanine nucleotide exchange factor subunit R06F6.8 Neighboring gene Uncharacterized protein Neighboring gene Mitotic chromosome and X-chromosome-associated protein mix-1 Neighboring gene BTB domain-containing protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Tissue- and paralogue-specific functions of acyl-CoA-binding proteins in lipid metabolism in Caenorhabditis elegans. Elle IC, et al. Biochem J, 2011 Jul 15. PMID 21539519
    2. Rege-1 promotes C. elegans survival by modulating IIS and TOR pathways. Tsai YT, et al. PLoS Genet, 2023 Aug. PMID 37556491, Free PMC Article
    3. Fatty acid desaturation and the regulation of adiposity in Caenorhabditis elegans. Brock TJ, et al. Genetics, 2007 Jun. PMID 17435249, Free PMC Article
    4. A Caenorhabditis elegans nutrient response system partially dependent on nuclear receptor NHR-49. Van Gilst MR, et al. Proc Natl Acad Sci U S A, 2005 Sep 20. PMID 16157872, Free PMC Article
    5. Antagonistic fungal enterotoxins intersect at multiple levels with host innate immune defences. Zhang X, et al. PLoS Genet, 2021 Jun. PMID 34166401, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables fatty-acyl-CoA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in fatty acid beta-oxidation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in lipid storage IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ACB domain-containing protein
    NP_001366707.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      10821031..10822391
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001381584.2 → NP_001366707.1  ACB domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q09603
      Conserved Domains (2) summary
      cd06558
      Location:129 → 326
      crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...
      cd00435
      Location:25 → 109
      ACBP; Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a ...
    Nucleotide Protein
    Heading Accession and Version

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