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    tps-2 Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 2;Trehalose-6-phosphate phosphatase C-terminal domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 3565050, updated on 9-Dec-2024

    Summary

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    Official Symbol
    tps-2
    Official Full Name
    Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 2;Trehalose-6-phosphate phosphatase C-terminal domain-containing protein
    Primary source
    WormBase:WBGene00006603
    Locus tag
    CELE_F19H8.1
    See related
    AllianceGenome:WB:WBGene00006603
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity and trehalose-phosphatase activity. Predicted to be involved in trehalose biosynthetic process and trehalose metabolism in response to stress. Is expressed in body wall musculature; hypodermis; intestine; muscle cell; and reproductive system. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See tps-2 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    14
    Sequence:
    Chromosome: II; NC_003280.10 (14600902..14610554)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene G_PROTEIN_RECEP_F1_2 domain-containing protein Neighboring gene Sodium/potassium-transporting ATPase subunit alpha Neighboring gene ShKT domain-containing protein Neighboring gene ncRNA Neighboring gene ADP-ribosylation factor-like protein 3 Neighboring gene MLt-TeN (mlt-10) related Neighboring gene tRNA Neighboring gene ncRNA Neighboring gene MLt-TeN (mlt-10) related

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Dehydration-induced tps gene transcripts from an anhydrobiotic nematode contain novel spliced leaders and encode atypical GT-20 family proteins. Goyal K, et al. Biochimie, 2005 Jun. PMID 15935281
    2. Elevated Trehalose Levels in C. elegans daf-2 Mutants Increase Stress Resistance, Not Lifespan. Rasulova M, et al. Metabolites, 2021 Feb 12. PMID 33673074, Free PMC Article
    3. Increased Protein Stability and Decreased Protein Turnover in the Caenorhabditis elegans Ins/IGF-1 daf-2 Mutant. Depuydt G, et al. J Gerontol A Biol Sci Med Sci, 2016 Dec. PMID 26865495, Free PMC Article
    4. daf-16/FoxO promotes gluconeogenesis and trehalose synthesis during starvation to support survival. Hibshman JD, et al. Elife, 2017 Oct 24. PMID 29063832, Free PMC Article
    5. Trehalose extends longevity in the nematode Caenorhabditis elegans. Honda Y, et al. Aging Cell, 2010 Aug. PMID 20477758

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables trehalose-phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in trehalose biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in trehalose biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in trehalose metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in trehalose metabolism in response to stress IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 2;Trehalose-6-phosphate phosphatase C-terminal domain-containing protein
    NP_001364816.1
    • Confirmed by transcript evidence
    NP_497035.3
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      14600902..14610554
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_064634.6 → NP_497035.3  Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_497035.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O45380, Q7YZT5
      Conserved Domains (3) summary
      cd03788
      Location:238 → 787
      GT1_TPS; Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a ...
      TIGR01484
      Location:934 → 1158
      HAD-SF-IIB; HAD-superfamily hydrolase, subfamily IIB
      TIGR02400
      Location:238 → 787
      trehalose_OtsA; alpha,alpha-trehalose-phosphate synthase [UDP-forming]

    2. NM_001377904.2 → NP_001364816.1  Trehalose-6-phosphate phosphatase C-terminal domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      U4PLZ2
      Conserved Domains (1) summary
      cl21460
      Location:135 → 177
      HAD_like; Haloacid Dehalogenase-like Hydrolases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O45380.3

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