lin-15B Protein lin-15B [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: lin-15B
Official Full Name: Protein lin-15B
Primary source: WormBase:WBGene00023497
Locus tag: CELE_ZK662.4
See related: AllianceGenome:WB:WBGene00023497
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable DNA binding activity and metal ion binding activity. Involved in negative regulation of Ras protein signal transduction; negative regulation of vulval development; and regulation of cell fate specification. Is expressed in several structures, including anal region; germ line; head muscle; oocyte; and somatic cell. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See lin-15B in Genome Data Viewer

Location:: chromosome: X

Exon count:: 8

Sequence:: Chromosome: X; NC_003284.9 (15726129..15731861)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These findings indicate that nos-1 and nos-2 activity is required in primordial germ cells to silence maternal transcripts inherited from the oocyte. We identify maternal lin-15B as a critical target of Nanos regulation that must be turned-over to establish MES methyltransferase dominance in primordial germ cells.
Title: Nanos promotes epigenetic reprograming of the germline by down-regulation of the THAP transcription factor LIN-15B.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

ZK662.4 (e-PCR)
- UniSTS:308294

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of Ras protein signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of vulval development	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of vulval development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of vulval development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell fate specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sex differentiation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info
located_in nucleus	NAS Non-traceable Author Statement more info	PubMed

General protein information

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Preferred Names: Protein lin-15B

NP_510587.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

15726129..15731861

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_078186.7 → NP_510587.1 Protein lin-15B [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_510587.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q27395, Q94409, Q94414

Conserved Domains (1) summary

smart00692
Location:1151 → 1206

DM3; Zinc finger domain in CG10631, C. elegans LIN-15B and human P52rIPK